We are analyzing https://link.springer.com/article/10.1007/bf01262570.

Title:
Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients | Supportive Care in Cancer
Description:
Cancer anorexia-cachexia syndrome (CACS), which is characterized by progressive weight loss (WL) and anorexia (A), is present in 50% of advanced cancer patients and in 80% of terminally ill cancer patients. One of the most controversial aspects of CACS is its oetiopathogenesis; experimental studies have identified certain cytokines [Tumour necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and gamma interferon (\gg-IFN)] as possible cofactors in the onset of the syndrome. The aim of our study was to investigate the correlation between serum levels of circulating cytokines and severity of CACS. The following series of parameters was indentified in 61 patients with advanced and terminal cancer: stage of disease; Karnofsky performance status (KPS) and clinical symptoms; biohumoral, anthropometric and immunological situation; level of circulating cytokines. All these parameters were evaluated for a possible link with WL/A. Our data do not show any significant correlation between circulating cytokines and WL/A. A direct correlation was identified between WL/A and nausea (P=0.03 andP<0.001, respectively) whereas inverse correlations were observed for both factors as regards arm circumference (P<0.001 for both), wrist circumference (P<0.001 for both), KPS (P<0.001 andP=0.003, respectively) and creatinine (P=0.005 andP=0.03, respectively). Other biochemical factors, such as haemoglobin, haematocrit, glycaemia, prealbumin, sodium and chlorine were also correlated with at least one of the two clinical parameters in question. Unexpected results were seen in the increases in CD20 and CD4 and in the CD4/CD8 ratio. Serum levels of these cytokines do not, therefore, appear to be critical in the onset of CACS. On the contrary, our findings confirmed the clinico-laboratory picture that is characteristic of CACS. If we consider the possibility that CACS is provoked by an aspecific response of the host
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cancer, google, scholar, necrosis, factor, patients, cachexia, article, phd, tumor, serum, cytokines, interleukin, tumour, cacs, access, oxford, privacy, cookies, content, levels, anorexia, circulating, clinical, data, publish, search, weight, loss, maltoni, laura, emanuela, factors, production, natl, immunol, clin, med, information, log, journal, research, care, alpha, correlate, fabbri, nanni, scarpi, amadori, syndrome,

Topics {✒️}

anticachectin/tumor necrosis factor month download article/chapter cachectin/tumor necrosis factor tumour necrosis factor tumour necrosis factor endotoxin-induced serum factor cancer anorexia-cachexia syndrome tumor necrosis factor article supportive care privacy choices/manage cookies full article pdf laura pezzi ph patients terminally ill oriana nanni ph emanuela flamini ph angela riccobon ph european economic area karnofsky performance status clinico-laboratory picture prolonged neoplastic attack o'connor jv lymphokineactivated killer cells operativa di biostatistica istituto oncologico romagnolo metastatic cancer treated laura fabbri ph conditions privacy policy melanoma cell line human cancer cachexia emanuela scarpi ph prognostic biomarkers palladino ma jr �emanuela scarpi ph experimental cancer cachexia systemic sclerosis patients raised serum levels check access instant access untreated cancer patients accepting optional cookies clinical cancer cachexia progressive weight loss oxford university press weight loss prior interleukin 1-induced pathophysiology human cancer patients cd4/cd8 ratio main content log journal finder publish advanced cancer patients

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         headline:Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients
         description:Cancer anorexia-cachexia syndrome (CACS), which is characterized by progressive weight loss (WL) and anorexia (A), is present in 50% of advanced cancer patients and in 80% of terminally ill cancer patients. One of the most controversial aspects of CACS is its oetiopathogenesis; experimental studies have identified certain cytokines [Tumour necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and gamma interferon (\gg-IFN)] as possible cofactors in the onset of the syndrome. The aim of our study was to investigate the correlation between serum levels of circulating cytokines and severity of CACS. The following series of parameters was indentified in 61 patients with advanced and terminal cancer: stage of disease; Karnofsky performance status (KPS) and clinical symptoms; biohumoral, anthropometric and immunological situation; level of circulating cytokines. All these parameters were evaluated for a possible link with WL/A. Our data do not show any significant correlation between circulating cytokines and WL/A. A direct correlation was identified between WL/A and nausea (P=0.03 andP<0.001, respectively) whereas inverse correlations were observed for both factors as regards arm circumference (P<0.001 for both), wrist circumference (P<0.001 for both), KPS (P<0.001 andP=0.003, respectively) and creatinine (P=0.005 andP=0.03, respectively). Other biochemical factors, such as haemoglobin, haematocrit, glycaemia, prealbumin, sodium and chlorine were also correlated with at least one of the two clinical parameters in question. Unexpected results were seen in the increases in CD20 and CD4 and in the CD4/CD8 ratio. Serum levels of these cytokines do not, therefore, appear to be critical in the onset of CACS. On the contrary, our findings confirmed the clinico-laboratory picture that is characteristic of CACS. If we consider the possibility that CACS is provoked by an aspecific response of the host's defence mechanisms against prolonged neoplastic attack, the increase in CD4 (helper lymphocytes) could be linked to the persistent response.
         datePublished:
         dateModified:
         pageStart:130
         pageEnd:135
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            Anorexia
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            Tumour necrosis factor
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            Nursing
            Nursing Research
            Pain Medicine
            Rehabilitation Medicine
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      headline:Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients
      description:Cancer anorexia-cachexia syndrome (CACS), which is characterized by progressive weight loss (WL) and anorexia (A), is present in 50% of advanced cancer patients and in 80% of terminally ill cancer patients. One of the most controversial aspects of CACS is its oetiopathogenesis; experimental studies have identified certain cytokines [Tumour necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and gamma interferon (\gg-IFN)] as possible cofactors in the onset of the syndrome. The aim of our study was to investigate the correlation between serum levels of circulating cytokines and severity of CACS. The following series of parameters was indentified in 61 patients with advanced and terminal cancer: stage of disease; Karnofsky performance status (KPS) and clinical symptoms; biohumoral, anthropometric and immunological situation; level of circulating cytokines. All these parameters were evaluated for a possible link with WL/A. Our data do not show any significant correlation between circulating cytokines and WL/A. A direct correlation was identified between WL/A and nausea (P=0.03 andP<0.001, respectively) whereas inverse correlations were observed for both factors as regards arm circumference (P<0.001 for both), wrist circumference (P<0.001 for both), KPS (P<0.001 andP=0.003, respectively) and creatinine (P=0.005 andP=0.03, respectively). Other biochemical factors, such as haemoglobin, haematocrit, glycaemia, prealbumin, sodium and chlorine were also correlated with at least one of the two clinical parameters in question. Unexpected results were seen in the increases in CD20 and CD4 and in the CD4/CD8 ratio. Serum levels of these cytokines do not, therefore, appear to be critical in the onset of CACS. On the contrary, our findings confirmed the clinico-laboratory picture that is characteristic of CACS. If we consider the possibility that CACS is provoked by an aspecific response of the host's defence mechanisms against prolonged neoplastic attack, the increase in CD4 (helper lymphocytes) could be linked to the persistent response.
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      dateModified:
      pageStart:130
      pageEnd:135
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         Anorexia
         Cachexia
         Tumour necrosis factor
         Interleukin
         Interferon
         Oncology
         Nursing
         Nursing Research
         Pain Medicine
         Rehabilitation Medicine
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