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Ultrastructural studies of young and old mouse neuromuscular junctions | Brain Cell Biology
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The ultrastructure of the neuromuscular junction of young and old male CBF-1 mice was analysed both qualitatively and quantitatively. The age-related findings were similar in both the phasic extensor digitorum longus muscle and the tonic soleus muscle but more pronounced in the latter. Presynaptic terminals of old mice compared to young showed decreases in nerve terminal area, mitochondria and synaptic vesicles, but increases in smooth endoplasmic reticulum, coated vesicles, cisternae, microtubules and probably neurofilaments. On the postsynaptic side there were increases in complexity of junctional folds and subsarcolemmal vesicles, and the appearance of lipofuscin deposits. Occasional denervated postsynaptic regions were encountered in old neuromuscular junctions, but the predominant characteristics of aging changes were not those of denervation. Rather, a unique and uniform process involving most of the population of nerve terminals, possibly of physiologically adaptive significance, appears to occur with age in both phasic and tonic limb muscles.
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google, scholar, pubmed, neuromuscular, article, skeletal, muscle, nerve, access, motor, privacy, cookies, content, journal, research, young, mouse, junctions, robbins, mice, vesicles, physiology, publish, search, neurocytology, ultrastructural, junction, smooth, endoplasmic, reticulum, aging, age, normal, cell, data, information, log, studies, fahim, ultrastructure, soleus, presynaptic, terminal, synaptic, open, march, discover, sprouting, mammalian, evidence,
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month download article/chapter smooth endoplasmic reticulum tonic soleus muscle disused soleus muscle mammalian neuromuscular junction frog neuromuscular junction deafferented skeletal muscle terminal axons found male cbf-1 mice mouse neuromuscular junctions nerve terminal area privacy choices/manage cookies related subjects full article pdf neuromuscular junction presynaptic nerve terminals tonic limb muscles mouse skeletal fibre skeletal muscle age-related findings check access instant access ultrastructure research suppl european economic area uniform process involving physiologically adaptive significance mammalian motor axons royal society series retrograde axonal transport neuromuscular junctions mice compared presynaptic terminals motor neuron disease motor end-plates cone cell endings conditions privacy policy accepting optional cookies evoked transmitter release synaptic vesicle membrane main content log young showed decreases skeletal muscles journal finder publish aged rats article log robbins rights neuromuscular system neuromuscular transmission article journal sarcoplasmic components
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- (1978) Can neuronal smooth endoplasmic reticulum function as a calcium reservoir?
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headline:Ultrastructural studies of young and old mouse neuromuscular junctions
description:The ultrastructure of the neuromuscular junction of young and old male CBF-1 mice was analysed both qualitatively and quantitatively. The age-related findings were similar in both the phasic extensor digitorum longus muscle and the tonic soleus muscle but more pronounced in the latter. Presynaptic terminals of old mice compared to young showed decreases in nerve terminal area, mitochondria and synaptic vesicles, but increases in smooth endoplasmic reticulum, coated vesicles, cisternae, microtubules and probably neurofilaments. On the postsynaptic side there were increases in complexity of junctional folds and subsarcolemmal vesicles, and the appearance of lipofuscin deposits. Occasional denervated postsynaptic regions were encountered in old neuromuscular junctions, but the predominant characteristics of aging changes were not those of denervation. Rather, a unique and uniform process involving most of the population of nerve terminals, possibly of physiologically adaptive significance, appears to occur with age in both phasic and tonic limb muscles.
datePublished:
dateModified:
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Neuromuscular Junction
Soleus Muscle
Presynaptic Terminal
Extensor Digitorum
Smooth Endoplasmic Reticulum
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Cell Biology
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Biological Microscopy
Developmental Biology
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headline:Ultrastructural studies of young and old mouse neuromuscular junctions
description:The ultrastructure of the neuromuscular junction of young and old male CBF-1 mice was analysed both qualitatively and quantitatively. The age-related findings were similar in both the phasic extensor digitorum longus muscle and the tonic soleus muscle but more pronounced in the latter. Presynaptic terminals of old mice compared to young showed decreases in nerve terminal area, mitochondria and synaptic vesicles, but increases in smooth endoplasmic reticulum, coated vesicles, cisternae, microtubules and probably neurofilaments. On the postsynaptic side there were increases in complexity of junctional folds and subsarcolemmal vesicles, and the appearance of lipofuscin deposits. Occasional denervated postsynaptic regions were encountered in old neuromuscular junctions, but the predominant characteristics of aging changes were not those of denervation. Rather, a unique and uniform process involving most of the population of nerve terminals, possibly of physiologically adaptive significance, appears to occur with age in both phasic and tonic limb muscles.
datePublished:
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Neuromuscular Junction
Soleus Muscle
Presynaptic Terminal
Extensor Digitorum
Smooth Endoplasmic Reticulum
Neurosciences
Neurobiology
Cell Biology
Life Sciences
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Biological Microscopy
Developmental Biology
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