We are analyzing https://link.springer.com/article/10.1007/bf01215981.

Title:
Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines | Journal of Cancer Research and Clinical Oncology
Description:
Cellular adhesion to extracellular matrix proteins via integrin molecules is a major factor in the process of invasion and metastasis of human tumor cells. Four human prostate cell lines were characterized according to the presence and quantity of integrin subunits, the ability of the cells to attach to extracellular substrates and the capacity of the cells to form tumors in severe combined immunodeficient (SCID) mice. All four human prostate cell lines expressed three to five integrins on their cell surfaces. The DU145, PC3 and 431P cells expressed primarily α3, α5, and α6 integrin at similar levels. These cell lines expressed the subunits β1, β3 and β4 with β1 predominant. The DU145 cells preferred attachment to fibronectin, followed by laminin and vitronectin. Approximately 50%–60% of the binding of DU145 cells to fibronectin and laminin was dependent on the function of α5β1 and α6 respectively. The cell line LNCaP differed in its low expression of the α3 subunit, 95% of cellular adhesion to fobronectin and laminin being integrin-dependent and its inability to attach to vitronectin, in spite of surface expression of αvβ3. All the cell lines except for LNCaP readily formed tumors within SCID mice and the expression of α3, α6, β1, and β4 integrin subunits was preserved in the resulting tumor tissue. The altered adhesion properties of the LNCaP cells may explain their altered tumorigenicity.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

google, scholar, pubmed, cell, cancer, integrin, cells, human, prostate, adhesion, res, article, biol, receptor, fibronectin, expression, integrins, characterization, extracellular, metastasis, lines, matrix, tumor, carcinoma, arizona, mice, laminin, vitronectin, subunit, access, growth, privacy, cookies, content, journal, research, subunits, scid, αvβ, fibroblasts, chung, lwk, monoclonal, analysis, information, publish, search, oncology, cellular, invasion,

Topics {✒️}

month download article/chapter cell lines expressed prostate carcinoma growth human prostate cancer platelet glycoproteins ic-iia human lung cancer human prostatic carcinoma human tumor cells clinical oncology aims mediating cell adhesion fibronectin receptor-deficient cells rat prostate fibroblasts prostatic cancer growth privacy choices/manage cookies cell adhesion molecules humanprostate cancer growth full article pdf platelet glycoproteins ic tumor cell dissemination circulating tumor cells lymphocyte adhesion receptor severe combined immunodeficient resulting tumor tissue altered adhesion properties scid mouse mutant cell lines collagen receptor complexes platelet gpiib-iiia von eschenbach ac oncogenically transformed cells european economic area automated microfiltration device proteolytically processed keratins van der geer promotes bacterial penetration steele gd jr elastin repeat peptide kolmogorov-smirnov test cell adhesion conditions privacy policy distinct adhesive properties arizona cancer center o'toole te integrin β subunit unexpected subunit composition accepting optional cookies extracellular matrix proteins extracellular matrix components specific monoclonal antibodies check access

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines
         description:Cellular adhesion to extracellular matrix proteins via integrin molecules is a major factor in the process of invasion and metastasis of human tumor cells. Four human prostate cell lines were characterized according to the presence and quantity of integrin subunits, the ability of the cells to attach to extracellular substrates and the capacity of the cells to form tumors in severe combined immunodeficient (SCID) mice. All four human prostate cell lines expressed three to five integrins on their cell surfaces. The DU145, PC3 and 431P cells expressed primarily α3, α5, and α6 integrin at similar levels. These cell lines expressed the subunits β1, β3 and β4 with β1 predominant. The DU145 cells preferred attachment to fibronectin, followed by laminin and vitronectin. Approximately 50%–60% of the binding of DU145 cells to fibronectin and laminin was dependent on the function of α5β1 and α6 respectively. The cell line LNCaP differed in its low expression of the α3 subunit, 95% of cellular adhesion to fobronectin and laminin being integrin-dependent and its inability to attach to vitronectin, in spite of surface expression of αvβ3. All the cell lines except for LNCaP readily formed tumors within SCID mice and the expression of α3, α6, β1, and β4 integrin subunits was preserved in the resulting tumor tissue. The altered adhesion properties of the LNCaP cells may explain their altered tumorigenicity.
         datePublished:
         dateModified:
         pageStart:637
         pageEnd:644
         sameAs:https://doi.org/10.1007/BF01215981
         keywords:
            Integrins
            Cell adhesion
            Human prostate cell lines
            Metastasis
            Oncology
            Cancer Research
            Internal Medicine
            Hematology
         image:
         isPartOf:
            name:Journal of Cancer Research and Clinical Oncology
            issn:
               1432-1335
               0171-5216
            volumeNumber:119
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Colette M. Witkowski
               affiliation:
                     name:University of Arizona College of Medicine
                     address:
                        name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Isaac Rabinovitz
               affiliation:
                     name:University of Arizona College of Medicine
                     address:
                        name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Raymond B. Nagle
               affiliation:
                     name:University of Arizona Collage of Medicine
                     address:
                        name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kit-Sahn D. Affinito
               affiliation:
                     name:University of Arizona Collage of Medicine
                     address:
                        name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anne E. Cress
               affiliation:
                     name:University of Arizona College of Medicine
                     address:
                        name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines
      description:Cellular adhesion to extracellular matrix proteins via integrin molecules is a major factor in the process of invasion and metastasis of human tumor cells. Four human prostate cell lines were characterized according to the presence and quantity of integrin subunits, the ability of the cells to attach to extracellular substrates and the capacity of the cells to form tumors in severe combined immunodeficient (SCID) mice. All four human prostate cell lines expressed three to five integrins on their cell surfaces. The DU145, PC3 and 431P cells expressed primarily α3, α5, and α6 integrin at similar levels. These cell lines expressed the subunits β1, β3 and β4 with β1 predominant. The DU145 cells preferred attachment to fibronectin, followed by laminin and vitronectin. Approximately 50%–60% of the binding of DU145 cells to fibronectin and laminin was dependent on the function of α5β1 and α6 respectively. The cell line LNCaP differed in its low expression of the α3 subunit, 95% of cellular adhesion to fobronectin and laminin being integrin-dependent and its inability to attach to vitronectin, in spite of surface expression of αvβ3. All the cell lines except for LNCaP readily formed tumors within SCID mice and the expression of α3, α6, β1, and β4 integrin subunits was preserved in the resulting tumor tissue. The altered adhesion properties of the LNCaP cells may explain their altered tumorigenicity.
      datePublished:
      dateModified:
      pageStart:637
      pageEnd:644
      sameAs:https://doi.org/10.1007/BF01215981
      keywords:
         Integrins
         Cell adhesion
         Human prostate cell lines
         Metastasis
         Oncology
         Cancer Research
         Internal Medicine
         Hematology
      image:
      isPartOf:
         name:Journal of Cancer Research and Clinical Oncology
         issn:
            1432-1335
            0171-5216
         volumeNumber:119
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Colette M. Witkowski
            affiliation:
                  name:University of Arizona College of Medicine
                  address:
                     name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Isaac Rabinovitz
            affiliation:
                  name:University of Arizona College of Medicine
                  address:
                     name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Raymond B. Nagle
            affiliation:
                  name:University of Arizona Collage of Medicine
                  address:
                     name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kit-Sahn D. Affinito
            affiliation:
                  name:University of Arizona Collage of Medicine
                  address:
                     name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anne E. Cress
            affiliation:
                  name:University of Arizona College of Medicine
                  address:
                     name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Cancer Research and Clinical Oncology
      issn:
         1432-1335
         0171-5216
      volumeNumber:119
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Arizona College of Medicine
      address:
         name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
         type:PostalAddress
      name:University of Arizona College of Medicine
      address:
         name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
         type:PostalAddress
      name:University of Arizona Collage of Medicine
      address:
         name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
         type:PostalAddress
      name:University of Arizona Collage of Medicine
      address:
         name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
         type:PostalAddress
      name:University of Arizona College of Medicine
      address:
         name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Colette M. Witkowski
      affiliation:
            name:University of Arizona College of Medicine
            address:
               name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
               type:PostalAddress
            type:Organization
      name:Isaac Rabinovitz
      affiliation:
            name:University of Arizona College of Medicine
            address:
               name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
               type:PostalAddress
            type:Organization
      name:Raymond B. Nagle
      affiliation:
            name:University of Arizona Collage of Medicine
            address:
               name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
               type:PostalAddress
            type:Organization
      name:Kit-Sahn D. Affinito
      affiliation:
            name:University of Arizona Collage of Medicine
            address:
               name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
               type:PostalAddress
            type:Organization
      name:Anne E. Cress
      affiliation:
            name:University of Arizona College of Medicine
            address:
               name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
      name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
      name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
      name:Department of Pathology, The Arizona Cancer Center, University of Arizona Collage of Medicine, Tucson, USA
      name:Department of Radiation Oncology, The Arizona Cancer Center, University of Arizona College of Medicine, Tucson, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(126)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.63s.

LINK . SPRINGER . COM {}