We are analyzing https://link.springer.com/article/10.1007/bf00812073.

Title:
Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum | Journal of Bioenergetics and Biomembranes
Description:
Rapid Ca2+ release from the sarcoplasmic reticulum (SR) can be triggered by either binding of heavy metals to a sulfhydryl (SH) group or by catalyzing the oxidation of endogenous groups to a disulfide. Ca2+ release has been monitored directly using isolated vesicle preparations or indirectly by monitoring phasic contractions in a skinned fiber preparation. SH oxidation triggered by addition of Cu2+ /mercaptans, phthalocyanine dyes, reactive disulfides, and various anthraquinones appears to involve a direct interaction with the Ca2+ release protein from the SR. A model is presented in which reversible oxidation and reduction of endogenous SH groups results in the opening and closing of the Ca2+ release channel from the SR.
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Keywords {🔍}

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Topics {✒️}

monitoring phasic contractions phthalocyanine dyes reactive disulfides month download article/chapter ca2+ release protein ca2+ release channel sarcoplasmic reticulum cu2+ /mercaptans anthraquinones appears ca2+ release privacy choices/manage cookies cell calcium 6 full article pdf european economic area isolated vesicle preparations skinned fiber preparation check access instant access conditions privacy policy portland state university main content log accepting optional cookies related subjects journal finder publish sulfhydryl t-tubule sh oxidation triggered article journal biomembranes aims endogenous groups article abramson article log privacy policy personal data books a article cite subscription content similar content optional cookies manage preferences oregon jonathan journal publish data protection essential cookies cookies skip abramson department institution subscribe usage analysis social media varying standards april 1989 volume 21

Questions {❓}

Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?

Schema {🗺️}

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         description:Rapid Ca2+ release from the sarcoplasmic reticulum (SR) can be triggered by either binding of heavy metals to a sulfhydryl (SH) group or by catalyzing the oxidation of endogenous groups to a disulfide. Ca2+ release has been monitored directly using isolated vesicle preparations or indirectly by monitoring phasic contractions in a skinned fiber preparation. SH oxidation triggered by addition of Cu2+ /mercaptans, phthalocyanine dyes, reactive disulfides, and various anthraquinones appears to involve a direct interaction with the Ca2+ release protein from the SR. A model is presented in which reversible oxidation and reduction of endogenous SH groups results in the opening and closing of the Ca2+ release channel from the SR.
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            calcium release
            sarcoplasmic reticulum
            phasic contractions
            mercaptans
            phthalocyanine dyes
            reactive disulfides
            anthraquinones
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            Organic Chemistry
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         calcium release
         sarcoplasmic reticulum
         phasic contractions
         mercaptans
         phthalocyanine dyes
         reactive disulfides
         anthraquinones
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         Biochemistry
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         Animal Anatomy / Morphology / Histology
         Animal Biochemistry
         Organic Chemistry
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