We are analyzing https://link.springer.com/article/10.1007/bf00694753.

Title:
Aberrant function of the Ras signal transduction pathway in human breast cancer | Breast Cancer Research and Treatment
Description:
Althoughras mutations are infrequent (approximately 5%) in breast cancers, there is considerable evidence that suggests that the pathways which Ras services may still be deregulated in breast cancer cells. The recent identification of many of the components of the Ras signal transduction pathway has defined a network of proto-oncogene proteins controlling diverse signaling events that regulate cell growth and differentiation. Consequently, mutations that perturb the function of any one component of this signal pathway may trigger the same oncogenic events as mutation ofras itself. Moreover, several Ras-related proteins have recently been demonstrated to possess the ability to trigger malignant transformation via signaling pathways shared with Ras proteins. Thus, it is possible that the aberrant function of Ras-related proteins may contribute to breast cancer development. Consequently, it is important not to dismiss the Ras pathway in the development of breast cancer merely because of the infrequent detection of mutations inras itself, but rather to consider the influence of aberrations upstream or downstream of Ras and of certain Ras-related proteins in the development of breast cancer. Finally, the critical importance of components upstream and downstream of Ras provides additional targets for rational drug design approaches to block the aberrant function of Ras signaling in human tumors.
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Keywords {🔍}

google, scholar, cell, ras, cancer, protein, breast, biol, proteins, human, nature, signaling, sci, usa, signal, cells, transformation, natl, science, kinase, function, proc, acad, transduction, oncogene, mol, article, pathway, clark, growth, activation, raf, gene, oncogenes, mccormick, domain, domains, pathways, res, cox, aberrant, rasrelated, malignant, pras, activity, privacy, cookies, content, research, oncogenic,

Topics {✒️}

mmtv/v-ha-ras ras-specific exchange factor extra-cellular-signal regulated kinases mitogen-activated protein kinase gtp-binding protein ran/tc4 c-ha-ras oncogene r-ras induces malignant ras signalling pathway inhibit ras-dependent growth month download article/chapter her2/neu proto-oncogene carboxyl-terminal cysteine residues small gtp-binding proteins map kinase kinase bcr-abl-induced oncogenesis serine/threonine kinase raf mmtv/c-myc genes ras p21-dependent inhibition amino-terminal regulatory domain theets-2 dna-binding domain receptor tyrosine kinases c-terminal sh2 region r-ras interacts mutation ofras induced nih/3t3 cells malignant tumor growth signaling pathways shared ras-related proteins diverse cell functions diverse signaling proteins ras-gap-mediated signaling gtp-binding proteins human breast cancer privacy choices/manage cookies raf-1 protein kinase amino-terminal region nuclearras-related polypeptide oncogenic ras signaling regulate cell growth cytoplasmic signaling proteins ras-related gtpases protein functionally related gap-related domain breast cancer cells her2/neu oncogene mutant ras proteins proteins regulating ras independent molecular pathways selective cleavage reaction geranylgeranyl-modified proteins

Questions {❓}

Cox AD, Der CJ: Protein prenylation: more than just glue?
Hall A:ras and GAP — who's controlling whom?
Khosravi-Far R, Cox AD, Kato K, Der CJ: Protein prenylation: key to ras function and cancer intervention?

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