We are analyzing https://link.springer.com/article/10.1007/bf00690603.

Title:
Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis | Cancer and Metastasis Reviews
Description:
The malignant progression of tumors is driven by the expression of oncogenes and loss of expression of tumor suppressor genes; factors that are intrinsic to cancer cells. The phenotypic changes brought about by the gain or loss of expression of oncogenes and tumor suppressor genes lead to the acquisition of malignant traits, namely, the ability to invade into and grow in ectopic tissue environments. Recently, however, focus in cancer research has widened from the cancer cell to include the surrounding tumor stroma as an integral player in the process of tumor progression. One of the areas in cancer research contributing to this enhanced appreciation of stromal involvement in tumor progression and metastasis is that of matrix metalloproteinases (MMPs). This review provides an overview of the characteristics of MMPs and discusses their role in the progression and metastasis of tumors. Initially, attention will focus on the regulation of MMPs in tumor cells but will switch to discourse on stromal expression of MMPs in tumors and speculation on the functional consequences of stromal expression of MMPs.
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Keywords {🔍}

google, scholar, cancer, cell, matrix, expression, metalloproteinase, tumor, cells, human, res, metalloproteinases, inhibitor, matrisian, progression, collagenase, gene, tissue, stromelysin, metastasis, biol, growth, stromal, natl, metastatic, carcinomas, sci, usa, expressed, fibroblasts, inhibition, research, article, invasion, regulation, activity, proc, acad, nature, mol, melanoma, breast, mmps, rat, kda, induction, gelatinase, matrilysin, colon, basset,

Topics {✒️}

cell-cell contact-mediated induction b16-bl6 murine melanoma b16-f10 melanoma cells sarcoma cell-free supernatants antisense rna-induced reduction transforming growth factor-betal month download article/chapter matrix metalloprotease inhibitorn-[2r-2 transfection withc-ha-ras glycosyl-phosphatidylinositol-anchored ncam membrane-type matrix metalloproteinase invasive tumour cells growth factor-regulated proteases cell growth-promoting activity proto-oncogenes c-fos c-ets gene expression human fibroblast collagenase basal cell carcinoma situ hybridization access 92-kda gelatinase/collagenase epidermal growth factor privacy choices/manage cookies du-145 cells increases spindle cell carcinomas type iv collagenases angiogenic potentialin vivo human colonic adenocarcinoma human neutrophil collagenase somatic cell hybridization basal cell carcinomas c-ha-ras human colon cancer human amnion invasion metastasis reviews aims human malignant lymphomas murine hemangioma growth collagenase gene expression human prostate cancer tumor suppressor genes basement membrane collagen matrix metalloproteinase matrilysin cell biology reduces tumor growth full article pdf cancer research contributing erythroid-potentiating activity erythroid potentiating activity swiss 3t3 cells de grossouvre pd hepatoma hybrid cells

Questions {❓}

Boshart M, Nitsch D, Schutz G: Extinction of gene expression in somatic cell hybrids - a reflection of important regulatory mechanisms?
Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?

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         collagenase
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         metastasis
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         general
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