We are analyzing https://link.springer.com/article/10.1007/bf00689638.

Title:
P-glycoprotein, multidrug resistance and tumor progression | Cancer and Metastasis Reviews
Description:
P-glycoprotein (Pgp) is a plasma membrane protein that was first characterised in multidrug resistant cell lines. The occurrence of Pgp in clinical tumors has been widely studied. Recent investigations have begun to focus on the relationship between Pgp detection in tumors and treatment outcome. In several types of tumors, detection of Pgp correlates with poor response to chemotherapy and shorter survival. P-glycoprotein overexpression often occurs upon relapse from chemotherapy but may also occur at the time of diagnosis. Studies of experimental rat liver carcinogenesis have shown that Pgp expression increases in late stages of carcinogenesis, suggesting that Pgp may be involved in tumor progression. While some of the Pgp isoforms are known to transport hydrophobic chemotherapeutic drugs out of tumor cells, the biologic effects of Pgp overexpression in tumor cells are not fully understood, because the spectrum of substrates for Pgp-mediated transport has not been determined. In the rat liver carcinoma model, strong expression of Pgp is associated with a highly vascular stroma, suggesting that Pgp in tumor cells may affect the connective tissue stroma. The regulation of Pgp appears to be complex, and little is known about how it is up-regulated during carcinogenesis. Further studies of the role of Pgp in malignancy may contribute to our understanding of molecular mechanisms which underlie tumor progression.
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month download article/chapter retinoic acid-induced differentiation natural p-gp inhibitor virus-positive hepatocellular carcinomas cell surface p-glycoprotein multidrug resistance p-glycoprotein multidrug-resistance gene expression rat mdr2 gene mammalian cell lines privacy choices/manage cookies multidrug resistance gene human cancer metastasis human colon carcinoma multidrug resistance protein acquired trait related p-glycoprotein gene metastasis reviews aims mhc-linked transporter full article pdf drug resistance gene multidrug resistance malignancies mediated multidrug resistance mouse multidrug resistance related subjects primary hepatocyte cultures plasma membrane protein mdr3/mdr1a gene van roon ma human mdr1 gene therapeutic implications lymph node metastasis virus transgenic mice p-glycoprotein isoforms p-glycoprotein expression normal human tissues fluorescent cellular indicators p53 gene dosage european economic area highly vascular stroma connective tissue stroma tissue specific manner o'brien jp oude elferink rpj high-dose verapamil 3-methylcholanthrene-mediated induction clinical drug resistance p-glycoprotein overexpression mdr-1/p-glycoprotein conditions privacy policy p-glycoprotein genes

Questions {❓}

Endicott JA, Ling V: The biochemistry of P-glycoprotein?

Schema {🗺️}

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