We are analyzing https://link.springer.com/article/10.1007/bf00666165.

Title:
Differentiation state and invasiveness of human breast cancer cell lines | Breast Cancer Research and Treatment
Description:
Eighteen breast cancer cell lines were examined for expression of markers of epithelial and fibroblastic differentiation: E-cadherin, desmoplakins, ZO-1, vimentin, keratin and β1 and β4 integrins. The cell lines were distributed along a spectrum of differentiation from epithelial to fibroblastic phenotypes. The most well-differentiated, epithelioid cell lines contained proteins characteristic of desmosomal, adherens and tight junctions, were adherent to one another on plastic and in the basement membrane matrix Matrigel and were keratin-positive and vimentin-negative. These cell lines were all weakly invasive in anin vitro chemoinvasion assay. The most poorly-differentiated, fibroblastic cell lines were E-cadherin-, desmoplakin- and ZO-1-negative and formed branching structures in Matrigel. They were vimentin-positive, contained only low levels of keratins and were highly invasive in thein vitro chemoinvasion assay. Of all of the markers analyzed, vimentin expression correlated best within vitro invasive ability and fibroblastic differentiation. In a cell line with unstable expression of vimentin, T47DCO, the cells that were invasive were of the fibroblastic type. The differentiation markers described here may be useful for analysis of clinical specimens and could potentially provide a more precise measure of differentiation grade yielding more power for predicting prognosis.
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Keywords {🔍}

google, scholar, cancer, cell, breast, expression, vimentin, pathol, human, lines, epithelial, article, ecadherin, res, differentiation, cells, adhesion, research, sommers, invasive, thompson, carcinomas, privacy, cookies, content, byers, torri, gelmann, fibroblastic, integrins, invasion, carcinoma, mammary, publish, search, markers, access, protein, growth, cellcell, birchmeier, tumor, biol, data, information, log, journal, state, invasiveness, keratin,

Topics {✒️}

uvomorulin-mediated cell-cell adhesion epithelial–mesenchymal transition cell-cell contacts mediated selective cell-cell adhesion month download article/chapter increased basement membrane-invasiveness high-grade prostate cancer fibroblastic cell lines squamous cell carcinomas cell growth human breast carcinomas invasion suppressor role accessory adhesion molecules human carcinoma cells human mammary gland privacy choices/manage cookies differentiation grade yielding full article pdf lobular breast carcinomas cell lines related subjects malignant breast epithelium glial filament protein cell line high-grade ductal e-cadherin expression metastatic gastric cancer malignant mammary tumours estrogen receptor mutations vitro invasive ability differentiation state poorly differentiated tumors cancer research 52 european economic area formed branching structures molecular family important conditions privacy policy low estrogen receptor restrict invasive behavior breast cancer differentiation grade accepting optional cookies lymph node metastasis van roy fm cell biol 118 cell physiol 150 cell biol 108 cell biol 113 cell biol 114 cell biology

Questions {❓}

Jones JL, Critchley DR, Walker RA: Alteration of stromal protein and integrin expression in breast-a marker of premalignant change?
Raymond WA, Leong AS-Y: Vimentin - A new prognostic parameter in breast carcinoma?

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         description:Eighteen breast cancer cell lines were examined for expression of markers of epithelial and fibroblastic differentiation: E-cadherin, desmoplakins, ZO-1, vimentin, keratin and β1 and β4 integrins. The cell lines were distributed along a spectrum of differentiation from epithelial to fibroblastic phenotypes. The most well-differentiated, epithelioid cell lines contained proteins characteristic of desmosomal, adherens and tight junctions, were adherent to one another on plastic and in the basement membrane matrix Matrigel and were keratin-positive and vimentin-negative. These cell lines were all weakly invasive in anin vitro chemoinvasion assay. The most poorly-differentiated, fibroblastic cell lines were E-cadherin-, desmoplakin- and ZO-1-negative and formed branching structures in Matrigel. They were vimentin-positive, contained only low levels of keratins and were highly invasive in thein vitro chemoinvasion assay. Of all of the markers analyzed, vimentin expression correlated best within vitro invasive ability and fibroblastic differentiation. In a cell line with unstable expression of vimentin, T47DCO, the cells that were invasive were of the fibroblastic type. The differentiation markers described here may be useful for analysis of clinical specimens and could potentially provide a more precise measure of differentiation grade yielding more power for predicting prognosis.
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      headline:Differentiation state and invasiveness of human breast cancer cell lines
      description:Eighteen breast cancer cell lines were examined for expression of markers of epithelial and fibroblastic differentiation: E-cadherin, desmoplakins, ZO-1, vimentin, keratin and β1 and β4 integrins. The cell lines were distributed along a spectrum of differentiation from epithelial to fibroblastic phenotypes. The most well-differentiated, epithelioid cell lines contained proteins characteristic of desmosomal, adherens and tight junctions, were adherent to one another on plastic and in the basement membrane matrix Matrigel and were keratin-positive and vimentin-negative. These cell lines were all weakly invasive in anin vitro chemoinvasion assay. The most poorly-differentiated, fibroblastic cell lines were E-cadherin-, desmoplakin- and ZO-1-negative and formed branching structures in Matrigel. They were vimentin-positive, contained only low levels of keratins and were highly invasive in thein vitro chemoinvasion assay. Of all of the markers analyzed, vimentin expression correlated best within vitro invasive ability and fibroblastic differentiation. In a cell line with unstable expression of vimentin, T47DCO, the cells that were invasive were of the fibroblastic type. The differentiation markers described here may be useful for analysis of clinical specimens and could potentially provide a more precise measure of differentiation grade yielding more power for predicting prognosis.
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