We are analyzing https://link.springer.com/article/10.1007/bf00662402.

Title:
Growth and metastasis of human breast carcinomas with Matrigel in athymic mice | Breast Cancer Research and Treatment
Description:
Immunodeficient athymic mice with human tumor xenografts provide an importantin vivo experimental model for cancer research. However, only a limited number of tumor types grow in these animals. For human breast carcinomas, the incidence of tumor-take is 6–15%. Recently, increased incidence of xenograft development in mice has been reported for various human tumors when the tumors were coinjected with Matrigel. We studied the development of human breast carcinoma xenografts in athymic mice with and without coinjection of Matrigel. Tumors developed in only 7.3% of enzyme-dispersed tumors injected subcutaneously in saline solution alone. None of these tumors metastasized to distant sites. On the other hand, 50% of enzymedispersed tumors coinjected with Matrigel developed xenografts; four out of five of these tumors metastasized to distant sites. Our data from the recent study suggest that, in athymic mice, Matrigel not only enhanced breast tumor growth but also facilitated tumor metastasis.
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Keywords {🔍}

cancer, google, scholar, breast, mice, human, metastasis, matrigel, tumor, article, athymic, nude, research, growth, tumors, res, carcinomas, privacy, cookies, carcinoma, price, content, data, publish, search, xenografts, access, martin, cells, basement, laminin, usa, information, log, journal, mehta, graves, hart, discover, natl, proc, fridman, kleinman, membrane, cell, liotta, download, illinois, chicago, springer,

Topics {✒️}

month download article/chapter human breast carcinoma breast cancer patients human breast carcinomas privacy choices/manage cookies human prostatic carcinoma matrigel developed xenografts full article pdf brain metastasis produced cancer research facilitated tumor metastasis european economic area recent study suggest her2/neu oncogene demonstrate clonal dominance anne shilkaitis & tapas athymic nude mice conditions privacy policy tumor types grow enhanced tumor growth accepting optional cookies murine tumor cells cancer metastasis reconstituted basement membrane check access laminin molecular domains instant access enzymedispersed tumors coinjected journal finder publish cancer res 40 cancer res 51 athymic mice kleinman hk cell differentiation human carcinomas price je cancer lett 11 related subjects human tumors privacy policy murine model usa rajeshwari books a alter metastasis metastasis reviews 8 tumor cells article log liotta la hart rights established human

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         description:Immunodeficient athymic mice with human tumor xenografts provide an importantin vivo experimental model for cancer research. However, only a limited number of tumor types grow in these animals. For human breast carcinomas, the incidence of tumor-take is 6–15%. Recently, increased incidence of xenograft development in mice has been reported for various human tumors when the tumors were coinjected with Matrigel. We studied the development of human breast carcinoma xenografts in athymic mice with and without coinjection of Matrigel. Tumors developed in only 7.3% of enzyme-dispersed tumors injected subcutaneously in saline solution alone. None of these tumors metastasized to distant sites. On the other hand, 50% of enzymedispersed tumors coinjected with Matrigel developed xenografts; four out of five of these tumors metastasized to distant sites. Our data from the recent study suggest that, in athymic mice, Matrigel not only enhanced breast tumor growth but also facilitated tumor metastasis.
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      headline:Growth and metastasis of human breast carcinomas with Matrigel in athymic mice
      description:Immunodeficient athymic mice with human tumor xenografts provide an importantin vivo experimental model for cancer research. However, only a limited number of tumor types grow in these animals. For human breast carcinomas, the incidence of tumor-take is 6–15%. Recently, increased incidence of xenograft development in mice has been reported for various human tumors when the tumors were coinjected with Matrigel. We studied the development of human breast carcinoma xenografts in athymic mice with and without coinjection of Matrigel. Tumors developed in only 7.3% of enzyme-dispersed tumors injected subcutaneously in saline solution alone. None of these tumors metastasized to distant sites. On the other hand, 50% of enzymedispersed tumors coinjected with Matrigel developed xenografts; four out of five of these tumors metastasized to distant sites. Our data from the recent study suggest that, in athymic mice, Matrigel not only enhanced breast tumor growth but also facilitated tumor metastasis.
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