We are analyzing https://link.springer.com/article/10.1007/bf00433505.

Title:
Gestational caffeine modifies offspring behaviour in mice | Psychopharmacology
Description:
Dams from two strains of mice, BALB/c and C57BR were treated during gestation with caffeine, at doses of about 60, 80 and 100 mg/kg/day, in their drinking water. The resulting offspring were behaviourally tested over a 6-month period commencing at age 9 months. When compared with controls, mice from dams that had received caffeine demonstrated longer latencies in a passive avoidance test, and differences were also noted for female C57BR offspring in activity and habituation measures. Having controlled as far as possible for post-natal maternal and environmental effects, the most likely conclusion is that caffeine has a direct pharmacological action on the foetus, and should therefore be classed as a behavioural teratogen in mice.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter passive avoidance test neuroleptic-induced behavioural supersensitivity cortical brain damage selective 6ohda-induced destruction behavioral profile assessment psychostimulant-induced locomotor activity behavioural teratogenesis privacy choices/manage cookies article psychopharmacology aims female sex hormones full article pdf caffeine-induced teratogenicity locomotor hyperactivity induced dopamine receptor binding avoidance behaviour postsynaptic dopaminergic sensitivity psychotropic drugs neonatal development female c57br offspring european economic area scope submit manuscript 100 mg/kg/day related subjects effet tératogène systématique somatic mammalian cells fresh-brewed coffee frontocortical dopaminergic innervation université claude-bernard rat fetal brain check access instant access conditions privacy policy 6-month period commencing postnatal caffeine exposure response-modulating functions post-natal maternal prenatal maternal stress research procedures accepting optional cookies medial cortical lesions offspring behaviour rat rotational model main content log direct pharmacological action swiss mice treated caffeine-treated rats avoidance conditioning journal finder publish genetics

Schema {🗺️}

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