We are analyzing https://link.springer.com/article/10.1007/bf00402783.

Title:
Brown adipose tissue in cancer patients: Possible cause of cancer-induced cachexia | Journal of Cancer Research and Clinical Oncology
Description:
Cachexia is a common manifestation of advanced cancer and frequently contributes to physical disability and mortality. An increased metabolic rate has been suggested to be one of the causes of cancer-induced cachexia, although the mechanisms producing this hypermetabolism remain unclear. The presence and activation of brown adipose tissue, a highly thermogenic tissue, may result in a hypermetabolic state and be partially responsible for weight loss in cancer patients. To investigate this hypothesis, we examined necropsy samples of peri-adrenal tissues using light microscopy to identify the prevalence of brown adipose tissue in 25 cachectic patients who died from cancer and 15 age-matched subjects who died from other illnesses. Brown adipose tissue was observed in 20 of the cancer patients (80%) compared to 2 of the age-matched subjects (13%). Therefore, our preliminary results indicate that a high prevalence of brown adipose tissue is associated with cancer-induced cachexia and may reflect an abnormal mechanism responsible for profound energy expenditure and weight loss.
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Topics {✒️}

month download article/chapter cedars-sinai medical center clinical oncology aims privacy choices/manage cookies brown adipose tissue cancer-induced cachexia highly thermogenic tissue full article pdf perirenal fat perirenal brown fats european economic area increased metabolic rate hypermetabolism remain unclear peri-adrenal tissues acta univ ouluensis conditions privacy policy examined necropsy samples 15 age-matched subjects age-matched subjects abnormal mechanism responsible profound energy expenditure variable age groups hospitalized cancer patients accepting optional cookies journal finder publish main content log cancer research check access rothwell nj instant access cancer cachexia hypermetabolic state related subjects article journal cancer res 38 privacy policy personal data clin res 26 books a calorigenesis induced cancer patients article log optional cookies advanced cancer manage preferences journal publish subscription content data protection article cite essential cookies

Schema {🗺️}

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