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Title:
Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis | Journal of Neurology
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The cerebrospinal fluid (CSF) was examined in 90 amyotrophic lateral sclerosis (ALS) patients and in 50 age-matched normal controls. Total protein concentration was significantly higher in ALS patients than in normal controls. CSF IgG and albumin, quantitatively determined by single radial immunodiffusion, were significantly increased in ALS. No difference in serum concentrations was observed between ALS patients and normal controls. On isoelectric focusing a clear-cut “fingerprint” pattern was observed in 11 of 12 cases. These findings support the hypothesis that blood-brain barrier damage occurs in ALS. The finding of a higher mononuclear cell count in young ALS patients is briefly discussed in the light of the hypothesis that an exogenous agent might be of some relevance in pathogenesis. An alteration of at least one of the CSF parameters considered was found in 45.5% of ALS cases.
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google, scholar, cerebrospinal, fluid, neurol, article, sclerosis, amyotrophic, lateral, csf, patients, neurology, isoelectric, focusing, access, privacy, cookies, content, journal, publish, search, protein, barrier, disease, data, information, log, research, findings, leonardi, abbruzzese, arata, normal, controls, igg, serum, bloodbrain, liquor, open, clinical, discover, proteins, motor, neuron, diseases, kjellin, acta, scand, neurological, download,
Topics {✒️}
motor neuron disease blood-brain barrier disruption amyotrophic lateral sclerosis clear-cut “fingerprint” pattern blood-csf barrier dysfunctions month download article/chapter cerebrospinal fluid proteins spinal muscular atrophies young als patients machine learning cerebrospinal fluid examination agarose isoelectric focusing privacy choices/manage cookies total protein concentration related subjects full article pdf als patients csf proteins check access instant access european economic area scope submit manuscript single radial immunodiffusion electron microscopical study recent evaluation graph als cases conditions privacy policy cerebrospinal fluid multiple sclerosis isoelectric focusing accepting optional cookies agar gel electrophoresis csf parameters considered journal finder publish vische rights als article journal serum concentrations serum evaluated protein profile article log kjellin kg article cite article leonardi privacy policy personal data books a normal controls acta neurol 998 neurological patients
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headline:Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis
description:The cerebrospinal fluid (CSF) was examined in 90 amyotrophic lateral sclerosis (ALS) patients and in 50 age-matched normal controls. Total protein concentration was significantly higher in ALS patients than in normal controls. CSF IgG and albumin, quantitatively determined by single radial immunodiffusion, were significantly increased in ALS. No difference in serum concentrations was observed between ALS patients and normal controls. On isoelectric focusing a clear-cut “fingerprint” pattern was observed in 11 of 12 cases. These findings support the hypothesis that blood-brain barrier damage occurs in ALS. The finding of a higher mononuclear cell count in young ALS patients is briefly discussed in the light of the hypothesis that an exogenous agent might be of some relevance in pathogenesis. An alteration of at least one of the CSF parameters considered was found in 45.5% of ALS cases.
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Amyotrophic lateral sclerosis
Cerebrospinal fluid
Blood-brain barrier
Isoelectric focusing
Neurology
Neurosciences
Neuroradiology
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description:The cerebrospinal fluid (CSF) was examined in 90 amyotrophic lateral sclerosis (ALS) patients and in 50 age-matched normal controls. Total protein concentration was significantly higher in ALS patients than in normal controls. CSF IgG and albumin, quantitatively determined by single radial immunodiffusion, were significantly increased in ALS. No difference in serum concentrations was observed between ALS patients and normal controls. On isoelectric focusing a clear-cut “fingerprint” pattern was observed in 11 of 12 cases. These findings support the hypothesis that blood-brain barrier damage occurs in ALS. The finding of a higher mononuclear cell count in young ALS patients is briefly discussed in the light of the hypothesis that an exogenous agent might be of some relevance in pathogenesis. An alteration of at least one of the CSF parameters considered was found in 45.5% of ALS cases.
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Cerebrospinal fluid
Blood-brain barrier
Isoelectric focusing
Neurology
Neurosciences
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