We are analyzing https://link.springer.com/article/10.1007/bf00296784.

Title:
Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain | Acta Neuropathologica
Description:
Pathways for drainage of interstitial fluid and cerebrospinal fluid from the rat brain were investigated by the injection of 2–5 μl Indian ink into cerebral white and grey matter and into the subarachnoid space over the vertex of the left frontal lobe. Animals were killed by formalin or glutaraldehyde perfusion 5 min-2 years after injection, and the distribution of ink over the surface of the brain, in 2-mm slices of brain cleared in cedar wood oil, in paraffin sections and by electron microscopy was documented. These investigations showed that carbon particles were distributed diffusely through the interstitial spaces of the white matter whereas they spread selectively along perivascular spaces in the grey matter outlining both arteries and veins and extending to surround capillaries within 1 h. Carbon particles were rapidly ingested by perivascular cells and, to some extent, by meningeal cells surrounding the larger vessels. Very little movement of carbon-labelled perivascular cells and perivascular macrophages was seen after 2 years. Carbon particles entering the subarachnoid space over the vertex of the cerebral hemispheres drained along selected paravascular and subfrontal pathways in the subarachnoid space to the cribriform plate and thence into nasal lymphatics and cervical lymph nodes. These studies demonstrate the diffuse spread of fluidborne tracers through cerebral white matter in the rat, the perivascular spread of tracer in grey matter and the compartmentalised directional flow or tracer through the subarachnoid space to the cribriform plate and nasal lymphatics. Furthermore, particulate matter selectively injected into perivascular spaces in rat grey matter is rapidly and efficiently ingested by perivascular cells.
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Keywords {🔍}

google, scholar, brain, perivascular, fluid, article, rat, weller, cerebrospinal, space, cells, drainage, cerebral, matter, subarachnoid, spaces, interstitial, access, study, cserr, hydrocephalus, privacy, cookies, content, cervical, ultrastructural, neuropathol, neurosurg, information, publish, research, search, acta, zhang, injection, grey, particles, spread, lymph, human, exp, experimental, neurol, res, data, log, journal, directional, compartmentalised, richards,

Topics {✒️}

month download article/chapter ed2-positive perivascular cells brain/immune system interactions carbon-labelled perivascular cells cerebral extracellular fluids rat cerebrospinal fluid full article pdf privacy choices/manage cookies cerebrospinal fluid drainage wessex medical trust human spinal meninges 14c-labelled cells meningeal cells surrounding related subjects hypertensive brain injury cerebrospinal fluid cerebral interstitial fluid check access instant access european economic area scope submit manuscript left frontal lobe cedar wood oil frontal skull base elsevier science publishers james gibson fund �paravascular’ fluid circulation brain infusion edema cerebral hemispheres drained conditions privacy policy cervical lymph nodes deep cervical lymph blood-brain barrier compartmentalised directional flow antigen-specific lymphocytes extracellular tracers cervical lymphatic obstruction grey matter outlining cerebral blood vessels brain tissue damage accepting optional cookies perivascular cells light microscopic findings subacute obstructive hydrocephalus virchow-robin space perivascular spaces cerebral white matter carbon particles entering main content log rat grey matter

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