We are analyzing https://link.springer.com/article/10.1007/bf00294809.

Title:
Neurotransmitters in the spinal cord dorsal horn in a model of painful neuropathy and in nerve crush | Acta Neuropathologica
Description:
We tested the hypothesis that neurochemical changes in the spinal cord dorsal horn associated with neuropathic pain states differ from those seen in association with non-painful neuropathies. Immunohistochemistry was performed on spinal cord sections from rats with a chronic constriction injury (CCI), which develop hyperalgesia, and from animals with a nerve crush injury, which do not develop hyperalgesia or other signs of a painful syndrome. Immunohistochemistry was quantified by computer-assisted densitometry. Calcitonin gene-related peptide (CGRP) immunoreactivity and substance P (SP) immunoreactivity were decreased from 1 to 4 weeks after injury in CCI and from 2 to 6 weeks in crush. Gammaaminobutyric acid immunoreactivity was unchanged in both conditions at all time points. Met-enkephalin (Metenk) immunoreactivity was increased in CCI and unchanged in crush. Although SP and CGRP are involved in pain transmission, we conclude that their decrease in immunoreactivity is not specific for the CCI model, but rather a more general event in nerve de- and regeneration. The increase in immunoreactivity for the opioid peptide Met-enk, however, was only seen in the late phase of CCI, and may be specific for conditions associated with neuropathic pain and its resolution.
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Keywords {🔍}

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Topics {✒️}

calcitonin gene-related peptide month download article/chapter spinal kappa-opioid agonists chronic constriction injury opioid peptide met-enk cutaneous c-fiberevoked responses immunoreactive spinal neurons dorsal root ganglion dorsal spinal cord spinal dorsal horn peripheral nerve injury spinal cord sections nerve crush injury system dorsal horn neurones spinal cord evoked spinal cord dynorphin superficial dorsal horn privacy choices/manage cookies full article pdf rat spinal cord related subjects dorsal root ganglia dorsal root potentials rat dorsal horn opioid gene expression experimental peripheral neuropathy pain-related behavior measure thermal nociception measuring themal nociception golgi impregnated neurons neuropathic pain mediated dorsal horn change spinal cord neuropeptides peripheral nerve lesions peripheral nerve section kappa opioid binding experimental nerve injuries primary afferent origin painful peripheral neuropathy electron microscopic study european economic area computer-assisted densitometry trigeminal nucleus caudalis innocuous skin stimuli spontaneous discharge originates axonal blockade induces vasoactive intestinal polypeptide la forte ra immunogold labeling techniques

Questions {❓}

Klein CM, Guillamondegui O, Krenek CD, La Forte Ra, Coggeshall RE (1991) Do neuropeptides in the dorsal horn change if the dorsal root ganglion cell death that normally accompanies peripheral nerve transection is prevented?

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