We are analyzing https://link.springer.com/article/10.1007/bf00294021.

Title:
Leukocytes in the urine after intravesical BCG treatment for superficial bladder cancer | Urolithiasis
Description:
Cellular immunologic reactions occurring in the bladder after intravesical treatment with bacillus Calmette-Guérin (BCG) were investigated by flow cytofluorometric analysis of leukocytes present in the urine. Urine specimens from 11 superficial bladder cancer patients were collected before and 5, 24, 48 and 72 h after repeated BCG instillations. Monoclonal antibodies specific for granulocytes, monocytes/macrophages, and T-and B-lymphocytes were used to characterize and quantify leukocyte subpopulations. The total number of cells in urine was found to be 2- to 485-fold increased 24 h after BCG administration. The predominant cell type present was the polymorphonuclear granulocyte, probably representing a defense mechanism against mycobacteria. The main mononuclear leukocytes in urine specimens were monocytes/macrophages and T-lymphocytes, indicating an ongoing immune response in the bladder wall. Although percentages of lymphocytes were low, T- and B-cells could be identified using a selective cell measurement procedure. In conclusion, a clear increase in the numbers of granulocytes, monocytes/macrophages and T-lymphocytes in urine after intravesical BCG administration was demonstrated, indicating local activation of the immune system.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Science
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

bladder, google, scholar, bcg, cancer, urine, article, intravesical, superficial, treatment, van, meijden, bacillus, urol, jong, calmetteguérin, leukocytes, steerenberg, debruyne, ruitenberg, access, privacy, cookies, content, research, boer, urology, apm, netherlands, publish, search, cells, cell, fmj, res, ratliff, analysis, data, information, log, journal, flow, vegt, cellular, patients, granulocytes, monocytesmacrophages, administration, immune, open,

Topics {✒️}

month download article/chapter cellular reaction flow cytofluorometric analysis intracavitary bacillus calmette-guérin intravesical bcg therapy bacillus calmette-guérin treatment related subjects superficial bladder cancer bacillus calmette-guérin urine sediment van der meijden full article pdf privacy choices/manage cookies superficial bladder tumors human bladder washings thiotepa treated bladders hla-dr expression urothelial bladder tumors advanced bladder carcinoma main mononuclear leukocytes de jong wh van leeuwen mjw check access instant access transitional cell carcinoma bcg-reactive responses intravesical bcg administration bladder cancer repeated bcg instillations european economic area scope submit manuscript quantify leukocyte subpopulations indicating local activation rabbit pleural spaces anti-tumor agent randomized prospective trial intravesical bcg treatment conditions privacy policy ongoing immune response de boer ec t-cell infiltration accepting optional cookies endovesical bcg-immunotherapy monoclonal antibodies specific mammalian immune system article log journal finder publish february 1991 volume 19 therapeutic model cancer immunotherapy

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Leukocytes in the urine after intravesical BCG treatment for superficial bladder cancer
         description:Cellular immunologic reactions occurring in the bladder after intravesical treatment with bacillus Calmette-Guérin (BCG) were investigated by flow cytofluorometric analysis of leukocytes present in the urine. Urine specimens from 11 superficial bladder cancer patients were collected before and 5, 24, 48 and 72 h after repeated BCG instillations. Monoclonal antibodies specific for granulocytes, monocytes/macrophages, and T-and B-lymphocytes were used to characterize and quantify leukocyte subpopulations. The total number of cells in urine was found to be 2- to 485-fold increased 24 h after BCG administration. The predominant cell type present was the polymorphonuclear granulocyte, probably representing a defense mechanism against mycobacteria. The main mononuclear leukocytes in urine specimens were monocytes/macrophages and T-lymphocytes, indicating an ongoing immune response in the bladder wall. Although percentages of lymphocytes were low, T- and B-cells could be identified using a selective cell measurement procedure. In conclusion, a clear increase in the numbers of granulocytes, monocytes/macrophages and T-lymphocytes in urine after intravesical BCG administration was demonstrated, indicating local activation of the immune system.
         datePublished:
         dateModified:
         pageStart:45
         pageEnd:50
         sameAs:https://doi.org/10.1007/BF00294021
         keywords:
            Intravesical BCG therapy
            Bladder cancer
            Urine sediment
            Flow cytofluorometry
            Cellular immunological reaction
            Urology
            Nephrology
            Medical Biochemistry
         image:
         isPartOf:
            name:Urological Research
            issn:
               1434-0879
               0300-5623
            volumeNumber:19
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:E. C. de Boer
               affiliation:
                     name:National Institute of Public Health and Environmental Protection (RIVM)
                     address:
                        name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:W. H. de Jong
               affiliation:
                     name:National Institute of Public Health and Environmental Protection (RIVM)
                     address:
                        name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:A. P. M. van der Meijden
               affiliation:
                     name:University Hospital Nijmegen
                     address:
                        name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Department of Urology
                     address:
                        name:Department of Urology, 's-Hertogenbosch, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:P. A. Steerenberg
               affiliation:
                     name:National Institute of Public Health and Environmental Protection (RIVM)
                     address:
                        name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:F. Witjes
               affiliation:
                     name:University Hospital Nijmegen
                     address:
                        name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:P. D. J. Vegt
               affiliation:
                     name:St. Elisabeth Hospital
                     address:
                        name:Department of Urology, St. Elisabeth Hospital, Leiderdorp, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:F. M. J. Debruyne
               affiliation:
                     name:University Hospital Nijmegen
                     address:
                        name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:E. J. Ruitenberg
               affiliation:
                     name:Central Laboratory of the Red Cross Blood Transfusion Service
                     address:
                        name:Central Laboratory of the Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Leukocytes in the urine after intravesical BCG treatment for superficial bladder cancer
      description:Cellular immunologic reactions occurring in the bladder after intravesical treatment with bacillus Calmette-Guérin (BCG) were investigated by flow cytofluorometric analysis of leukocytes present in the urine. Urine specimens from 11 superficial bladder cancer patients were collected before and 5, 24, 48 and 72 h after repeated BCG instillations. Monoclonal antibodies specific for granulocytes, monocytes/macrophages, and T-and B-lymphocytes were used to characterize and quantify leukocyte subpopulations. The total number of cells in urine was found to be 2- to 485-fold increased 24 h after BCG administration. The predominant cell type present was the polymorphonuclear granulocyte, probably representing a defense mechanism against mycobacteria. The main mononuclear leukocytes in urine specimens were monocytes/macrophages and T-lymphocytes, indicating an ongoing immune response in the bladder wall. Although percentages of lymphocytes were low, T- and B-cells could be identified using a selective cell measurement procedure. In conclusion, a clear increase in the numbers of granulocytes, monocytes/macrophages and T-lymphocytes in urine after intravesical BCG administration was demonstrated, indicating local activation of the immune system.
      datePublished:
      dateModified:
      pageStart:45
      pageEnd:50
      sameAs:https://doi.org/10.1007/BF00294021
      keywords:
         Intravesical BCG therapy
         Bladder cancer
         Urine sediment
         Flow cytofluorometry
         Cellular immunological reaction
         Urology
         Nephrology
         Medical Biochemistry
      image:
      isPartOf:
         name:Urological Research
         issn:
            1434-0879
            0300-5623
         volumeNumber:19
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:E. C. de Boer
            affiliation:
                  name:National Institute of Public Health and Environmental Protection (RIVM)
                  address:
                     name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:W. H. de Jong
            affiliation:
                  name:National Institute of Public Health and Environmental Protection (RIVM)
                  address:
                     name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. P. M. van der Meijden
            affiliation:
                  name:University Hospital Nijmegen
                  address:
                     name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Department of Urology
                  address:
                     name:Department of Urology, 's-Hertogenbosch, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:P. A. Steerenberg
            affiliation:
                  name:National Institute of Public Health and Environmental Protection (RIVM)
                  address:
                     name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:F. Witjes
            affiliation:
                  name:University Hospital Nijmegen
                  address:
                     name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:P. D. J. Vegt
            affiliation:
                  name:St. Elisabeth Hospital
                  address:
                     name:Department of Urology, St. Elisabeth Hospital, Leiderdorp, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:F. M. J. Debruyne
            affiliation:
                  name:University Hospital Nijmegen
                  address:
                     name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:E. J. Ruitenberg
            affiliation:
                  name:Central Laboratory of the Red Cross Blood Transfusion Service
                  address:
                     name:Central Laboratory of the Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Urological Research
      issn:
         1434-0879
         0300-5623
      volumeNumber:19
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Institute of Public Health and Environmental Protection (RIVM)
      address:
         name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
         type:PostalAddress
      name:National Institute of Public Health and Environmental Protection (RIVM)
      address:
         name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
         type:PostalAddress
      name:University Hospital Nijmegen
      address:
         name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
         type:PostalAddress
      name:Department of Urology
      address:
         name:Department of Urology, 's-Hertogenbosch, The Netherlands
         type:PostalAddress
      name:National Institute of Public Health and Environmental Protection (RIVM)
      address:
         name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
         type:PostalAddress
      name:University Hospital Nijmegen
      address:
         name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
         type:PostalAddress
      name:St. Elisabeth Hospital
      address:
         name:Department of Urology, St. Elisabeth Hospital, Leiderdorp, The Netherlands
         type:PostalAddress
      name:University Hospital Nijmegen
      address:
         name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
         type:PostalAddress
      name:Central Laboratory of the Red Cross Blood Transfusion Service
      address:
         name:Central Laboratory of the Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:E. C. de Boer
      affiliation:
            name:National Institute of Public Health and Environmental Protection (RIVM)
            address:
               name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
               type:PostalAddress
            type:Organization
      name:W. H. de Jong
      affiliation:
            name:National Institute of Public Health and Environmental Protection (RIVM)
            address:
               name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
               type:PostalAddress
            type:Organization
      name:A. P. M. van der Meijden
      affiliation:
            name:University Hospital Nijmegen
            address:
               name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
               type:PostalAddress
            type:Organization
            name:Department of Urology
            address:
               name:Department of Urology, 's-Hertogenbosch, The Netherlands
               type:PostalAddress
            type:Organization
      name:P. A. Steerenberg
      affiliation:
            name:National Institute of Public Health and Environmental Protection (RIVM)
            address:
               name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
               type:PostalAddress
            type:Organization
      name:F. Witjes
      affiliation:
            name:University Hospital Nijmegen
            address:
               name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
               type:PostalAddress
            type:Organization
      name:P. D. J. Vegt
      affiliation:
            name:St. Elisabeth Hospital
            address:
               name:Department of Urology, St. Elisabeth Hospital, Leiderdorp, The Netherlands
               type:PostalAddress
            type:Organization
      name:F. M. J. Debruyne
      affiliation:
            name:University Hospital Nijmegen
            address:
               name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
               type:PostalAddress
            type:Organization
      name:E. J. Ruitenberg
      affiliation:
            name:Central Laboratory of the Red Cross Blood Transfusion Service
            address:
               name:Central Laboratory of the Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
      name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
      name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
      name:Department of Urology, 's-Hertogenbosch, The Netherlands
      name:Laboratory for Pathology, National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands
      name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
      name:Department of Urology, St. Elisabeth Hospital, Leiderdorp, The Netherlands
      name:Department of Urology, University Hospital Nijmegen, Nijmegen, The Netherlands
      name:Central Laboratory of the Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(59)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.32s.

LINK . SPRINGER . COM {}