We are analyzing https://link.springer.com/article/10.1007/bf00163962.

Title:
A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein | Immunogenetics
Description:
Human mannan-binding protein (MBP) is a serum lectin participating in the innate immune defence. Low MBP concentrations are explained by the dominant action of a point mutation at codon 54 of the MBP gene in Eskimos, partially in Caucasians, but not in Africans. A previously described point mutation at codon 57 was very frequent (0.23) in East Africans, low in Caucasians (0.02), and absent in Eskimos. The African population only conformed to Hardy-Weinberg expectation when assuming the existence of an unknown allele, which was subsequently found as a point mutation at codon 52. This allele appeared with a relatively high frequency (0.05) in both Africans and Caucasians, but was absent in Eskimos. Hardy-Weinberg equilibrium is now seen in the investigated ethnic groups. All cases of MBP deficiency may be explained by these three variants.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Non-Profit & Charity

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,603,724 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don't see any clear sign of profit-making.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

google, scholar, protein, gene, article, human, mannanbinding, thiel, garred, mannosebinding, exp, privacy, cookies, content, immunogenetics, allele, madsen, svejgaard, mbp, low, mutation, codon, binding, turner, data, publish, search, frequent, polymorphism, kurtzhals, lars, lectin, point, eskimos, africans, access, nature, immunol, denmark, information, log, journal, research, structural, lamm, ryder, serum, caucasians, deficiency, populations,

Topics {✒️}

human mannose-binding protein human mannan-binding protein innate immune defence month download article/chapter mannose binding protein mannose-binding protein bidirectional solid-phase sequencing investigated ethnic groups mannan-binding protein mannan binding protein serum lectin participating c-type lectin human plasma increase privacy choices/manage cookies full article pdf related subjects point mutation partial protein characterization article immunogenetics aims estimating gene frequencies acute-phase reactant acute phase response dna sequencing gene-counting method low serum concentrations european economic area hardy-weinberg expectation hardy-weinberg equilibrium medium vessel vasculitis sickle-cell trait subtertian malarial infection shares sequence homology classical complement pathway chain-terminating inhibitors base compositionindependent hybridization conditions privacy policy national university hospital skejby university hospital frequent allele accepting optional cookies complement deficiency syndrome check access instant access structural polymorphism low mbp concentrations january 1994 volume 40 journal finder publish article log group gene frequency

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein
         description:Human mannan-binding protein (MBP) is a serum lectin participating in the innate immune defence. Low MBP concentrations are explained by the dominant action of a point mutation at codon 54 of the MBP gene in Eskimos, partially in Caucasians, but not in Africans. A previously described point mutation at codon 57 was very frequent (0.23) in East Africans, low in Caucasians (0.02), and absent in Eskimos. The African population only conformed to Hardy-Weinberg expectation when assuming the existence of an unknown allele, which was subsequently found as a point mutation at codon 52. This allele appeared with a relatively high frequency (0.05) in both Africans and Caucasians, but was absent in Eskimos. Hardy-Weinberg equilibrium is now seen in the investigated ethnic groups. All cases of MBP deficiency may be explained by these three variants.
         datePublished:
         dateModified:
         pageStart:37
         pageEnd:44
         sameAs:https://doi.org/10.1007/BF00163962
         keywords:
            Codon
            Ethnic Group
            Frequent Allele
            Point Mutation
            Immune Defence
            Immunology
            Human Genetics
            Gene Function
            Cell Biology
            Allergology
         image:
         isPartOf:
            name:Immunogenetics
            issn:
               1432-1211
               0093-7711
            volumeNumber:40
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Hans O. Madsen
               affiliation:
                     name:Rigshospitalet
                     address:
                        name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:P. Garred
               affiliation:
                     name:Rigshospitalet
                     address:
                        name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Joergen A. L. Kurtzhals
               affiliation:
                     name:National University Hospital
                     address:
                        name:Department of Infectious Diseases, Centre for Medical Parasitology, Rigshospitalet, National University Hospital, Copenhagen N, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lars U. Lamm
               affiliation:
                     name:Skejby University Hospital
                     address:
                        name:Department of Clinical Immunology, Skejby University Hospital, Aarhus N, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lars P. Ryder
               affiliation:
                     name:Rigshospitalet
                     address:
                        name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Steffen Thiel
               affiliation:
                     name:Aarhus University
                     address:
                        name:Institute of Medical Microbiology, Aarhus University, Aarhus C, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Arne Svejgaard
               affiliation:
                     name:Rigshospitalet
                     address:
                        name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein
      description:Human mannan-binding protein (MBP) is a serum lectin participating in the innate immune defence. Low MBP concentrations are explained by the dominant action of a point mutation at codon 54 of the MBP gene in Eskimos, partially in Caucasians, but not in Africans. A previously described point mutation at codon 57 was very frequent (0.23) in East Africans, low in Caucasians (0.02), and absent in Eskimos. The African population only conformed to Hardy-Weinberg expectation when assuming the existence of an unknown allele, which was subsequently found as a point mutation at codon 52. This allele appeared with a relatively high frequency (0.05) in both Africans and Caucasians, but was absent in Eskimos. Hardy-Weinberg equilibrium is now seen in the investigated ethnic groups. All cases of MBP deficiency may be explained by these three variants.
      datePublished:
      dateModified:
      pageStart:37
      pageEnd:44
      sameAs:https://doi.org/10.1007/BF00163962
      keywords:
         Codon
         Ethnic Group
         Frequent Allele
         Point Mutation
         Immune Defence
         Immunology
         Human Genetics
         Gene Function
         Cell Biology
         Allergology
      image:
      isPartOf:
         name:Immunogenetics
         issn:
            1432-1211
            0093-7711
         volumeNumber:40
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Hans O. Madsen
            affiliation:
                  name:Rigshospitalet
                  address:
                     name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:P. Garred
            affiliation:
                  name:Rigshospitalet
                  address:
                     name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joergen A. L. Kurtzhals
            affiliation:
                  name:National University Hospital
                  address:
                     name:Department of Infectious Diseases, Centre for Medical Parasitology, Rigshospitalet, National University Hospital, Copenhagen N, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lars U. Lamm
            affiliation:
                  name:Skejby University Hospital
                  address:
                     name:Department of Clinical Immunology, Skejby University Hospital, Aarhus N, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lars P. Ryder
            affiliation:
                  name:Rigshospitalet
                  address:
                     name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Steffen Thiel
            affiliation:
                  name:Aarhus University
                  address:
                     name:Institute of Medical Microbiology, Aarhus University, Aarhus C, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Arne Svejgaard
            affiliation:
                  name:Rigshospitalet
                  address:
                     name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Immunogenetics
      issn:
         1432-1211
         0093-7711
      volumeNumber:40
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Rigshospitalet
      address:
         name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
         type:PostalAddress
      name:Rigshospitalet
      address:
         name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
         type:PostalAddress
      name:National University Hospital
      address:
         name:Department of Infectious Diseases, Centre for Medical Parasitology, Rigshospitalet, National University Hospital, Copenhagen N, Denmark
         type:PostalAddress
      name:Skejby University Hospital
      address:
         name:Department of Clinical Immunology, Skejby University Hospital, Aarhus N, Denmark
         type:PostalAddress
      name:Rigshospitalet
      address:
         name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
         type:PostalAddress
      name:Aarhus University
      address:
         name:Institute of Medical Microbiology, Aarhus University, Aarhus C, Denmark
         type:PostalAddress
      name:Rigshospitalet
      address:
         name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Hans O. Madsen
      affiliation:
            name:Rigshospitalet
            address:
               name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
               type:PostalAddress
            type:Organization
      name:P. Garred
      affiliation:
            name:Rigshospitalet
            address:
               name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
               type:PostalAddress
            type:Organization
      name:Joergen A. L. Kurtzhals
      affiliation:
            name:National University Hospital
            address:
               name:Department of Infectious Diseases, Centre for Medical Parasitology, Rigshospitalet, National University Hospital, Copenhagen N, Denmark
               type:PostalAddress
            type:Organization
      name:Lars U. Lamm
      affiliation:
            name:Skejby University Hospital
            address:
               name:Department of Clinical Immunology, Skejby University Hospital, Aarhus N, Denmark
               type:PostalAddress
            type:Organization
      name:Lars P. Ryder
      affiliation:
            name:Rigshospitalet
            address:
               name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
               type:PostalAddress
            type:Organization
      name:Steffen Thiel
      affiliation:
            name:Aarhus University
            address:
               name:Institute of Medical Microbiology, Aarhus University, Aarhus C, Denmark
               type:PostalAddress
            type:Organization
      name:Arne Svejgaard
      affiliation:
            name:Rigshospitalet
            address:
               name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
      name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
      name:Department of Infectious Diseases, Centre for Medical Parasitology, Rigshospitalet, National University Hospital, Copenhagen N, Denmark
      name:Department of Clinical Immunology, Skejby University Hospital, Aarhus N, Denmark
      name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
      name:Institute of Medical Microbiology, Aarhus University, Aarhus C, Denmark
      name:Tissue Typing Laboratory of the Department of Clinical Immunology, Rigshospitalet, Copenhagen N, Denmark
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(58)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.24s.

LINK . SPRINGER . COM {}