We are analyzing https://link.springer.com/chapter/10.1007/978-981-15-1025-0_3.

Title:
Assembly and Regulation of CRL Ubiquitin Ligases | SpringerLink
Description:
Cullin-RING ubiquitin ligases (CRLs) determine the substrate specificity of ubiquitination reactions, and substrates are recruited to the cullin core through binding to their cognate substrate receptor modules. Because a family of substrate receptors compete for the...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Assembly and Regulation of CRL Ubiquitin Ligases
      pageEnd:46
      pageStart:33
      image:https://media.springernature.com/w153/springer-static/cover/book/978-981-15-1025-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Cullin-RING Ligases and Protein Neddylation
         isbn:
            978-981-15-1025-0
            978-981-15-1024-3
         type:Book
      publisher:
         name:Springer Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Kankan Wang
            affiliation:
                  name:Purdue University
                  address:
                     name:Department of Biochemistry, Purdue University, West Lafayette, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Raymond J. Deshaies
            affiliation:
                  name:Amgen, One Amgen Center Way
                  address:
                     name:Amgen, One Amgen Center Way, Thousand Oaks, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xing Liu
            affiliation:
                  name:Purdue University
                  address:
                     name:Department of Biochemistry, Purdue University, West Lafayette, USA
                     type:PostalAddress
                  type:Organization
                  name:Center for Plant Biology, Purdue University
                  address:
                     name:Center for Plant Biology, Purdue University, West Lafayette, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:NEDD8, Neddylation, Cullin, CRLs, SCF, Cand1, Ubiquitination, F-box proteins
      description:Cullin-RING ubiquitin ligases (CRLs) determine the substrate specificity of ubiquitination reactions, and substrates are recruited to the cullin core through binding to their cognate substrate receptor modules. Because a family of substrate receptors compete for the same cullin core, the assembly and activity of CRLs are dynamically regulated to fulfill the needs of the cell to adapt to the changing pool of proteins demanding ubiquitination. Cullins are modified by NEDD8, a ubiquitin-like protein. This process, referred to as neddylation, promotes the E3 activity of CRLs by inducing conformational rearrangement in the Cullin-RING catalytic core. Cand1 is a cullin-associated protein whose binding is excluded by cullin neddylation. Although early biochemical studies suggested that Cand1 inhibits CRL activity, genetic studies revealed its positive role in ubiquitination. Emerging evidence from kinetic and quantitative proteomic studies demonstrated that Cand1 stimulates assembly of new Skp1-Cul1-F-box protein (SCF) complexes by exchanging the Skp1-F-box protein substrate receptor modules. Furthermore, aided by refined experimental design as well as computational simulation, an attractive model has been developed in which substrate, neddylation cycle and Cand1-mediated “adaptive exchange” collaborate to maintain the dynamics of the cellular SCF repertoire. Here, we review and discuss recent advances that have deepened our understanding of CRL regulation.
      datePublished:2020
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Book:
      name:Cullin-RING Ligases and Protein Neddylation
      isbn:
         978-981-15-1025-0
         978-981-15-1024-3
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Purdue University
      address:
         name:Department of Biochemistry, Purdue University, West Lafayette, USA
         type:PostalAddress
      name:Amgen, One Amgen Center Way
      address:
         name:Amgen, One Amgen Center Way, Thousand Oaks, USA
         type:PostalAddress
      name:Purdue University
      address:
         name:Department of Biochemistry, Purdue University, West Lafayette, USA
         type:PostalAddress
      name:Center for Plant Biology, Purdue University
      address:
         name:Center for Plant Biology, Purdue University, West Lafayette, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Kankan Wang
      affiliation:
            name:Purdue University
            address:
               name:Department of Biochemistry, Purdue University, West Lafayette, USA
               type:PostalAddress
            type:Organization
      name:Raymond J. Deshaies
      affiliation:
            name:Amgen, One Amgen Center Way
            address:
               name:Amgen, One Amgen Center Way, Thousand Oaks, USA
               type:PostalAddress
            type:Organization
      name:Xing Liu
      affiliation:
            name:Purdue University
            address:
               name:Department of Biochemistry, Purdue University, West Lafayette, USA
               type:PostalAddress
            type:Organization
            name:Center for Plant Biology, Purdue University
            address:
               name:Center for Plant Biology, Purdue University, West Lafayette, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry, Purdue University, West Lafayette, USA
      name:Amgen, One Amgen Center Way, Thousand Oaks, USA
      name:Department of Biochemistry, Purdue University, West Lafayette, USA
      name:Center for Plant Biology, Purdue University, West Lafayette, USA
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