We are analyzing https://link.springer.com/chapter/10.1007/978-94-017-9050-5_5.

Title:
RXRs: Collegial Partners | SpringerLink
Description:
Retinoid X Receptors (RXR) were initially identified as nuclear receptors binding with stereo-selectivity the vitamin A derivative 9-cis retinoic acid, although the relevance of this molecule as endogenous activator of RXRs is still elusive. Importantly, within the...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:RXRs: Collegial Partners
      pageEnd:102
      pageStart:75
      image:https://media.springernature.com/w153/springer-static/cover/book/978-94-017-9050-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level
         isbn:
            978-94-017-9050-5
            978-94-017-9049-9
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Federica Gilardi
            affiliation:
                  name:University of Lausanne
                  address:
                     name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Béatrice Desvergne
            affiliation:
                  name:University of Lausanne
                  address:
                     name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Nuclear Receptor, Constitutive Androstane Receptor, Heterodimerization Partner, Nuclear Receptor Binding, Chicken Ovalbumin Upstream Promoter Transcription
      description:Retinoid X Receptors (RXR) were initially identified as nuclear receptors binding with stereo-selectivity the vitamin A derivative 9-cis retinoic acid, although the relevance of this molecule as endogenous activator of RXRs is still elusive. Importantly, within the nuclear receptor superfamily, RXRs occupy a peculiar place, as they are obligatory partners for a number of other nuclear receptors, thus integrating the corresponding signaling pathways. In this chapter, we describe the structural features allowing RXR to form homo- and heterodimers, and the functional consequences of this unique ability. Furthermore, we discuss the importance of studying RXR activity at a genome-wide level in order to comprehensively address the biological implications of their action that is fundamental to understand to what extent RXRs could be exploited as new therapeutic targets.
      datePublished:2014
      isAccessibleForFree:
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Book:
      name:The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level
      isbn:
         978-94-017-9050-5
         978-94-017-9049-9
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Lausanne
      address:
         name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
         type:PostalAddress
      name:University of Lausanne
      address:
         name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Federica Gilardi
      affiliation:
            name:University of Lausanne
            address:
               name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
               type:PostalAddress
            type:Organization
      name:Béatrice Desvergne
      affiliation:
            name:University of Lausanne
            address:
               name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
      name:Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

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