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Title:
MACPF/CDC Proteins - Agents of Defence, Attack and Invasion | SpringerLink
Description:
This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.
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Keywords {π}
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Topics {βοΈ}
bi-component pore-forming proteins bacterial cholesterol-dependent cytolysins key pore-forming protein macpf/cdc super family cholesterol-dependent cytolysins benjamin bacterial pathogenesis deadly disease-causing agents biophysical approaches membrane attack complex/perforin macpf/cdc proteins pore-forming proteins device instant download cholesterol dependent cytolysins macpf/cdcs cholesterol-dependent cytolysin privacy choices/manage cookies macpf proteins target cell membranes water-soluble state historical overview gisou robert gilbert special chapter pdf read vertebrate immune system interesting proteins function super family members book series evolutionary entomology unexpected structural similarity chemistry/food science european economic area subcellular biochemistry cancer jerome thiery mauro dalla serra affiliations national institute biophysical techniques conditions privacy policy accepting optional cookies medicine/public health macpf-domain social media efficient agents journal finder publish gregor anderluh pore formation check access top access access licence comprehensive overview
Questions {β}
- Fungal MACPF-Like Proteins and Aegerolysins: Bi-component Pore-Forming Proteins?
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Book:
image:https://media.springernature.com/w153/springer-static/cover/book/978-94-017-8881-6
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
publisher:
name:Springer Netherlands
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
editor:
name:Gregor Anderluh
affiliation:
name:
address:
name:National Institute of Chemistry, Ljubljana, Slovenia, Laboratory for Molecular Biology and Nanobiotechnology, Ljubljana, Slovenia
type:PostalAddress
type:Organization
type:Person
name:Robert Gilbert
affiliation:
name:
address:
name:Division of Structural Biology, University of Oxford Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
type:PostalAddress
type:Organization
type:Person
keywords:MACPF/CDC superfamily, bacterial pathogenesis, biophysical approaches, immunity, pore forming proteins, Entomology
description:This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical
copyrightYear:2014
name:MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
numberOfPages:11
isbn:978-94-017-8881-6
copyrightHolder:
name:Springer Science+Business Media Dordrecht
type:Organization
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name:Springer Science+Business Media Dordrecht
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Person:
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affiliation:
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type:PostalAddress
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type:PostalAddress
type:Organization
PostalAddress:
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name:Division of Structural Biology, University of Oxford Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
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