We are analyzing https://link.springer.com/chapter/10.1007/978-94-007-7359-2_12.

Title:
Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases | SpringerLink
Description:
Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. It is constitutively up-regulated in several cancer types and has an important role in tumor progression, acidification and...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Kaluz S, Kaluzova M, Liao SY, Lerman M, Stanbridge EJ (2009) Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show?

Schema {🗺️}

ScholarlyArticle:
      headline:Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases
      pageEnd:254
      pageStart:221
      image:https://media.springernature.com/w153/springer-static/cover/book/978-94-007-7359-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
         isbn:
            978-94-007-7359-2
            978-94-007-7358-5
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Narges K. Tafreshi
            affiliation:
                  name:H. Lee Moffitt Cancer Center and Research Institute
                  address:
                     name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mark C. Lloyd
            affiliation:
                  name:H. Lee Moffitt Cancer Center and Research Institute
                  address:
                     name:Analytical Microscopy Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marilyn M. Bui
            affiliation:
                  name:H. Lee Moffitt Cancer Center and Research Institute
                  address:
                     name:Analytical Microscopy Core Facility and Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert J. Gillies
            affiliation:
                  name:H. Lee Moffitt Cancer Center and Research Institute
                  address:
                     name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David L. Morse
            affiliation:
                  name:H. Lee Moffitt Cancer Center and Research Institute
                  address:
                     name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Carbonic anhydrase IX, Carbonic anhydrase XII, Tumor hypoxia, Imaging, HIF-1, Acid-mediated invasion, Cancer, Antibody, Small molecular probes, Fluorescent sulfonamide
      description:Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. It is constitutively up-regulated in several cancer types and has an important role in tumor progression, acidification and metastasis. High expression of CAIX generally correlates with poor prognosis and is related to a decrease in the disease-free interval following successful therapy. Therefore, it is considered as a prognostic indicator in oncology. In this review, we describe CAIX regulation and its role in tumor hypoxia, acidification and metastasis. In addition, the molecular imaging of CAIX and its potential for use in cancer detection, diagnosis, staging, and for use in following therapy response is discussed. Both antibodies and small molecular weight compounds have been used for targeted imaging of CAIX expression. The use of CAIX expression as an attractive and promising candidate marker for systemic anticancer therapy is also discussed.
      datePublished:2014
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Book:
      name:Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
      isbn:
         978-94-007-7359-2
         978-94-007-7358-5
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:H. Lee Moffitt Cancer Center and Research Institute
      address:
         name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
         type:PostalAddress
      name:H. Lee Moffitt Cancer Center and Research Institute
      address:
         name:Analytical Microscopy Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
         type:PostalAddress
      name:H. Lee Moffitt Cancer Center and Research Institute
      address:
         name:Analytical Microscopy Core Facility and Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
         type:PostalAddress
      name:H. Lee Moffitt Cancer Center and Research Institute
      address:
         name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
         type:PostalAddress
      name:H. Lee Moffitt Cancer Center and Research Institute
      address:
         name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
         type:PostalAddress
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Person:
      name:Narges K. Tafreshi
      affiliation:
            name:H. Lee Moffitt Cancer Center and Research Institute
            address:
               name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
               type:PostalAddress
            type:Organization
      name:Mark C. Lloyd
      affiliation:
            name:H. Lee Moffitt Cancer Center and Research Institute
            address:
               name:Analytical Microscopy Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
               type:PostalAddress
            type:Organization
      name:Marilyn M. Bui
      affiliation:
            name:H. Lee Moffitt Cancer Center and Research Institute
            address:
               name:Analytical Microscopy Core Facility and Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
               type:PostalAddress
            type:Organization
      name:Robert J. Gillies
      affiliation:
            name:H. Lee Moffitt Cancer Center and Research Institute
            address:
               name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
               type:PostalAddress
            type:Organization
      name:David L. Morse
      affiliation:
            name:H. Lee Moffitt Cancer Center and Research Institute
            address:
               name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
      name:Analytical Microscopy Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
      name:Analytical Microscopy Core Facility and Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
      name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
      name:Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
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