We are analyzing https://link.springer.com/chapter/10.1007/978-94-007-4525-4_3.

Title:
Megabase Replication Domains Along the Human Genome: Relation to Chromatin Structure and Genome Organisation | SpringerLink
Description:
In higher eukaryotes, the absence of specific sequence motifs, marking the origins of replication has been a serious hindrance to the understanding of (i) the mechanisms that regulate the spatio-temporal replication program, and (ii) the links between origins...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Bogan JA, Natale DA, Depamphilis ML (2000) Initiation of eukaryotic DNA replication: conservative or liberal?
Gierlik A, Kowalczuk M, Mackiewicz P, Dudek MR, Cebrat S (2000) Is there replication-associated mutational pressure in the Saccharomyces cerevisiae genome?

Schema {🗺️}

ScholarlyArticle:
      headline:Megabase Replication Domains Along the Human Genome: Relation to Chromatin Structure and Genome Organisation
      pageEnd:80
      pageStart:57
      image:https://media.springernature.com/w153/springer-static/cover/book/978-94-007-4525-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Epigenetics: Development and Disease
         isbn:
            978-94-007-4525-4
            978-94-007-4524-7
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Benjamin Audit
            affiliation:
                  name:Université de Lyon
                  address:
                     name:Université de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
                  name:Ecole Normale Supérieure de Lyon
                  address:
                     name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Lamia Zaghloul
            affiliation:
                  name:Université de Lyon
                  address:
                     name:Université de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
                  name:Ecole Normale Supérieure de Lyon
                  address:
                     name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Antoine Baker
            affiliation:
                  name:Université de Lyon
                  address:
                     name:Université de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
                  name:Ecole Normale Supérieure de Lyon
                  address:
                     name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alain Arneodo
            affiliation:
                  name:Université de Lyon
                  address:
                     name:Université de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
                  name:Ecole Normale Supérieure de Lyon
                  address:
                     name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chun-Long Chen
            affiliation:
                  name:Centre de Génétique Moléculaire, CNRS
                  address:
                     name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yves d’Aubenton-Carafa
            affiliation:
                  name:Centre de Génétique Moléculaire, CNRS
                  address:
                     name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Claude Thermes
            affiliation:
                  name:Centre de Génétique Moléculaire, CNRS
                  address:
                     name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Wavelet Transform, Replication Origin, Nucleosome Position, Open Chromatin, Nucleosome Occupancy
      description:In higher eukaryotes, the absence of specific sequence motifs, marking the origins of replication has been a serious hindrance to the understanding of (i) the mechanisms that regulate the spatio-temporal replication program, and (ii) the links between origins activation, chromatin structure and transcription. In this chapter, we review the partitioning of the human genome into megabased-size replication domains delineated as N-shaped motifs in the strand compositional asymmetry profiles. They collectively span 28.3% of the genome and are bordered by more than 1,000 putative replication origins. We recapitulate the comparison of this partition of the human genome with high-resolution experimental data that confirms that replication domain borders are likely to be preferential replication initiation zones in the germline. In addition, we highlight the specific distribution of experimental and numerical chromatin marks along replication domains. Domain borders correspond to particular open chromatin regions, possibly encoded in the DNA sequence, and around which replication and transcription are highly coordinated. These regions also present a high evolutionary breakpoint density, suggesting that susceptibility to breakage might be linked to local open chromatin fiber state. Altogether, this chapter presents a compartmentalization of the human genome into replication domains that are landmarks of the human genome organization and are likely to play a key role in genome dynamics during evolution and in pathological situations.
      datePublished:2013
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      isbn:
         978-94-007-4525-4
         978-94-007-4524-7
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      name:Springer Netherlands
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Université de Lyon
      address:
         name:Université de Lyon, Lyon, France
         type:PostalAddress
      name:Ecole Normale Supérieure de Lyon
      address:
         name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
         type:PostalAddress
      name:Université de Lyon
      address:
         name:Université de Lyon, Lyon, France
         type:PostalAddress
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         name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
         type:PostalAddress
      name:Université de Lyon
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         name:Université de Lyon, Lyon, France
         type:PostalAddress
      name:Ecole Normale Supérieure de Lyon
      address:
         name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
         type:PostalAddress
      name:Université de Lyon
      address:
         name:Université de Lyon, Lyon, France
         type:PostalAddress
      name:Ecole Normale Supérieure de Lyon
      address:
         name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
         type:PostalAddress
      name:Centre de Génétique Moléculaire, CNRS
      address:
         name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
         type:PostalAddress
      name:Centre de Génétique Moléculaire, CNRS
      address:
         name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
         type:PostalAddress
      name:Centre de Génétique Moléculaire, CNRS
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         name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
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Person:
      name:Benjamin Audit
      affiliation:
            name:Université de Lyon
            address:
               name:Université de Lyon, Lyon, France
               type:PostalAddress
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            address:
               name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
               type:PostalAddress
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      email:[email protected]
      name:Lamia Zaghloul
      affiliation:
            name:Université de Lyon
            address:
               name:Université de Lyon, Lyon, France
               type:PostalAddress
            type:Organization
            name:Ecole Normale Supérieure de Lyon
            address:
               name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
               type:PostalAddress
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      name:Antoine Baker
      affiliation:
            name:Université de Lyon
            address:
               name:Université de Lyon, Lyon, France
               type:PostalAddress
            type:Organization
            name:Ecole Normale Supérieure de Lyon
            address:
               name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
               type:PostalAddress
            type:Organization
      name:Alain Arneodo
      affiliation:
            name:Université de Lyon
            address:
               name:Université de Lyon, Lyon, France
               type:PostalAddress
            type:Organization
            name:Ecole Normale Supérieure de Lyon
            address:
               name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
               type:PostalAddress
            type:Organization
      name:Chun-Long Chen
      affiliation:
            name:Centre de Génétique Moléculaire, CNRS
            address:
               name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
               type:PostalAddress
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      name:Yves d’Aubenton-Carafa
      affiliation:
            name:Centre de Génétique Moléculaire, CNRS
            address:
               name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
               type:PostalAddress
            type:Organization
      name:Claude Thermes
      affiliation:
            name:Centre de Génétique Moléculaire, CNRS
            address:
               name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Université de Lyon, Lyon, France
      name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
      name:Université de Lyon, Lyon, France
      name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
      name:Université de Lyon, Lyon, France
      name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
      name:Université de Lyon, Lyon, France
      name:Laboratoire de Physique, CNRS, Ecole Normale Supérieure de Lyon, Lyon, France
      name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
      name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
      name:Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France
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