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Title:
In Vivo Behavior of Liposomes: Interactions with the Mononuclear Phagocyte System and Implications for Drug Targeting | SpringerLink
Description:
Several years before Bangham et al. (1965a,b) formulated the concept of the liposome as a closed compartment separated from its aqueous environment by one or more lipid bilayers, and even longer before GREGORIADIS and Ryman (1972a) first suggested the use of such...
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Keywords {🔍}

google, scholar, liposomes, cas, pubmed, biophys, acta, biochim, cells, scherphof, uptake, cancer, drug, biochem, liver, res, unilamellar, rat, van, vivo, liposome, sci, gregoriadis, effect, macrophages, delivery, phospholipid, targeting, vitro, vesicles, eds, lipid, cell, interaction, acad, kupffer, small, fidler, proc, papahadjopoulos, roerdink, effects, human, usa, activity, muramyl, cholesterol, york, plasma, biol,

Topics {✒️}

ecto-nad+-glyco-hydrolase ligand-targeted liposomes liposome-entrapped [14c] cytosine-d-arabinofuranoside liposome-encapsulated murine interferon-gamma lipid-mediated dna-transfection procedure ecto-nad+-glycohydrolase ligands water-insoluble cytostatic agent 5′-o-dipalmitoyl-5-fluoro-2′-deoxyuridine liposome-encapsulated cytosine arabinoside high density lipo–proteins 2-dioleoyl-m-glycero-3-phosphocholine liposome-encapsulated sv40 dna applying phospholipid/steroid mixtures iiposome-encapsulated antimicrobial agents liposome-encapsulated dichloromethylene diphosphonate liposome-encapsulated dichloromethylene phosphonate chronic doxorubicin-induced cariotoxicity phos-phatidylcholine liposomes induced fc receptor–mediated transcytosis iiposome-encapsulated muramyl dipeptide target-oriented anticancer drugs spin-label phospholipid hapten human c-reactive protein comparative long-term study transfer-stimulating plasma factor bovine sphingomyelin/cholesterol liposomes human apolipoprotein a-iv liposome-encapsulated muramyl dipeptide unilamellar sphingomyelin/cholesterol liposomes drug carrier system plasma-stabilized liposomes composed galactoside-specific receptor organ-specific serum opsonins efficient drug carrier specific antibody-coated liposomes targeted drug delivery oleic acid-phosphatidylethanolamine liposomes privacy choices/manage cookies high density lipoproteins entrapped anti-cancer drugs lymphatic drug delivery drug-delivery vehicles 14c-dimyristoyl phosphatidylcholine human blood monocytes van der meulen download preview pdf stratum corneum lipids small unilamellar lipsomes gadoliniumchloride-induced shifts intravenously injected protein plasma-induced dissolution

Questions {❓}

Desmukh DS, Bear WD, Brockerhoff H (1981) Can intact liposomes be adsorbed in the gut?
Senior J, Gregoriadis G (1982b) Is the half-life circulating liposomes determined by changes in their permeability?

Schema {🗺️}

ScholarlyArticle:
      headline:In Vivo Behavior of Liposomes: Interactions with the Mononuclear Phagocyte System and Implications for Drug Targeting
      pageEnd:327
      pageStart:285
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-75862-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Targeted Drug Delivery
         isbn:
            978-3-642-75862-1
            978-3-642-75864-5
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:G. L. Scherphof
            affiliation:
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      keywords:Kupffer Cell, Liposomal Membrane, Small Unilamellar Vesicle, Muramyl Dipeptide, Liposomal Bilayer
      description:Several years before Bangham et al. (1965a,b) formulated the concept of the liposome as a closed compartment separated from its aqueous environment by one or more lipid bilayers, and even longer before GREGORIADIS and Ryman (1972a) first suggested the use of such liposomes as a potential drug carrier system, intravenous administration of aqueous dispersions of phospholipids was proposed as an anti-atherogenic treatment, facilitating the elimination of cholesterol from the body (Friedman et al. 1957). Even before that, a patent was obtained for the creation of a local depot of steroids, created by applying phospholipid/steroid mixtures, which clearly must have had the structural features of what we now call liposomes (Johnson 1934, cited according to Pagano and Weinstein 1978). However, the enormous boost in liposome literature that we have seen in more recent years did not start before the early 1970s, when Gregoriadis and Ryman (1972b) proposed the enzyme-loaded liposome as an approach to the treatment of (lysosomal) storage diseases. Ever since then, we have seen an exponential growth of literature on the potentials of the liposome as a drug carrier system, culminating over the past 3 or 4 years in a large number of reports on clinical trials concerning a limited number of applications. Much of the work published on liposomes deals with their in vivo behavior, both from a fundamental point of view and with respect to direct applications. Although a considerable share of this latter work serves to moderate the over-enthusiastic conclusions frequently drawn from in vitro experiments with liposomes and cells, it cannot be denied that sometimes spectacular results are reported, mostly on the therapeutic utility of liposomes in animal models of disease.
      datePublished:1991
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Book:
      name:Targeted Drug Delivery
      isbn:
         978-3-642-75862-1
         978-3-642-75864-5
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      name:Springer Berlin Heidelberg
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