We are analyzing https://link.springer.com/chapter/10.1007/978-3-642-55580-0_3.

Title:
Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk | SpringerLink
Description:
The steroid hormone 1,25 dihydroxyvitamin D3is thought to protect against breast cancer. Its actions are mediated via the vitamin D receptor (VDR) and a number of polymorphisms in the VDR gene have been identified, some of which may alter susceptibility to breast...
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Topics {✒️}

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Questions {❓}

Cooper GS, Umbach DM (1996) Are vitamin D receptor polymorphisms associated with bone mineral density?

Schema {🗺️}

ScholarlyArticle:
      headline:Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk
      pageEnd:54
      pageStart:43
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-55580-0.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Vitamin D Analogs in Cancer Prevention and Therapy
         isbn:
            978-3-642-55580-0
            978-3-642-62435-3
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michelle Guy
            affiliation:
                  name:St. George’s Hospital Medical School
                  address:
                     name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lorraine C. Lowe
            affiliation:
                  name:St. George’s Hospital Medical School
                  address:
                     name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Deborah Bretherton-Watt
            affiliation:
                  name:St. George’s Hospital Medical School
                  address:
                     name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Janine L. Mansi
            affiliation:
                  name:St. George’s Hospital Medical School
                  address:
                     name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kay W. Colston
            affiliation:
                  name:St. George’s Hospital Medical School
                  address:
                     name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Breast Cancer, Breast Cancer Risk, Receptor Gene Polymorphism, TaqI Polymorphism, BsmI Polymorphism
      description:The steroid hormone 1,25 dihydroxyvitamin D3is thought to protect against breast cancer. Its actions are mediated via the vitamin D receptor (VDR) and a number of polymorphisms in the VDR gene have been identified, some of which may alter susceptibility to breast cancer. This study has investigated whether specific VDR gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Female breast cancer patients (n=313) and control women with a negative screening mammogram (n=410) were recruited and their VDR polymorphisms were determined. The 30 VDR polymorphism BsmI was significantly associated with breast cancer risk; odds ratio bb vs. BB genotype =1.79 (95% CI, 1.12–C2.86; P=0.0221). In addition, over 70% of seven commonly used breast cancer cell lines were found to have the at-risk genotype bb. The 50 FokI gene variant was not associated with breast cancer risk. Further investigations into how these different genotypes may affect the functional mechanisms of the VDR will provide a better strategy for identifying women at risk of breast cancer and for developing improved treatments.
      datePublished:2003
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      name:Vitamin D Analogs in Cancer Prevention and Therapy
      isbn:
         978-3-642-55580-0
         978-3-642-62435-3
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      name:Springer Berlin Heidelberg
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      name:St. George’s Hospital Medical School
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      name:Michelle Guy
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               name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
               type:PostalAddress
            type:Organization
      name:Lorraine C. Lowe
      affiliation:
            name:St. George’s Hospital Medical School
            address:
               name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
               type:PostalAddress
            type:Organization
      name:Deborah Bretherton-Watt
      affiliation:
            name:St. George’s Hospital Medical School
            address:
               name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
               type:PostalAddress
            type:Organization
      name:Janine L. Mansi
      affiliation:
            name:St. George’s Hospital Medical School
            address:
               name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
               type:PostalAddress
            type:Organization
      name:Kay W. Colston
      affiliation:
            name:St. George’s Hospital Medical School
            address:
               name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
               type:PostalAddress
            type:Organization
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      name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
      name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
      name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
      name:Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, London, UK
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