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Title:
Gut Microbes, Diet, and Cancer | SpringerLink
Description:
An expanding body of evidence supports a role for gut microbes in the etiology of cancer. Previously, the focus was on identifying individual bacterial species that directly initiate or promote gastrointestinal malignancies; however, the capacity of gut microbes to...
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Keywords {๐}
google, scholar, pubmed, cas, article, cancer, human, gut, microbiol, bacteria, acid, nutr, colorectal, risk, metabolism, res, research, biochem, gastrointestinal, activity, colon, review, environ, biol, fecal, lampe, dietary, bile, intestinal, steroid, microflora, excretion, appl, meat, prev, colonic, analysis, diet, role, microbial, microbiota, clin, med, microbiome, effect, epidemiol, nature, gastroenterol, food, naples,
Topics {โ๏ธ}
month download article/chapter n-nitroso compound exposure beta-glucuronidase gene gus fluorescent gentamicin-thallous-carbonate sulfate-supplemented drinking water isolated intestinal micro-organisms host-archaeal-bacterial mutualism pro-carcinogenic gene expression specific butyrate-producing bacteria endogenous colonic n-nitrosation understanding microbe-induced cancers adenosine-5โฒ-phosphosulfate reductase genes serum lipopolysaccharide-binding protein mutation-specific combination chemoprevention sulfate-reducing bacteriaโprevalence meyskens fl jr culture-independent analysis lateral gene transfer secondary bile acid privacy choices/manage cookies exp biol med transit-induced increase serum bile acids endogenous n-nitrosation dietary amino acids beta-glucuronidase activity device instant download de kok mc observational research methods host immune system synthetic lethality approach editor information editors van den berg cell uptake assays inhibits hdac activity gut epithelial cells fecal bile acids fecal water genotoxicity polyamine catabolism contributes capillary electrophoresis time hristova kr human serum measured gut microbial community bacterial myrosinase activity conference paper advances sulfate-reducing microorganisms human colonic strain de pascual-teresa research design ii national cancer institute
Questions {โ}
- Conterno L, Fava F, Viola R et al (2011) Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?
- Mager DL (2006) Bacteria and cancer: cause, coincidence or cure?
- Silvester KR, Cummings JH (1995) Does digestibility of meat protein help explain large bowel cancer risk?
Schema {๐บ๏ธ}
ScholarlyArticle:
headline:Gut Microbes, Diet, and Cancer
pageEnd:399
pageStart:377
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-642-38007-5.jpg
genre:
Medicine
Medicine (R0)
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name:Advances in Nutrition and Cancer
isbn:
978-3-642-38007-5
978-3-642-38006-8
type:Book
publisher:
name:Springer Berlin Heidelberg
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url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
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author:
name:Meredith A. J. Hullar
affiliation:
name:Fred Hutchinson Cancer Research Center
address:
name:Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA
type:PostalAddress
type:Organization
type:Person
name:Andrea N. Burnett-Hartman
affiliation:
name:Fred Hutchinson Cancer Research Center
address:
name:Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA
type:PostalAddress
type:Organization
type:Person
name:Johanna W. Lampe
affiliation:
name:Fred Hutchinson Cancer Research Center
address:
name:Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA
type:PostalAddress
type:Organization
name:University of Washington
address:
name:Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Microbiota, Gut microbiome, Gut microbial community, Cancer prevention
description:An expanding body of evidence supports a role for gut microbes in the etiology of cancer. Previously, the focus was on identifying individual bacterial species that directly initiate or promote gastrointestinal malignancies; however, the capacity of gut microbes to influence systemic inflammation and other downstream pathways suggests that the gut microbial community may also affect risk of cancer in tissues outside of the gastrointestinal tract. Functional contributions of the gut microbiota that may influence cancer susceptibility in the broad sense include (1) harvesting otherwise inaccessible nutrients and/or sources of energy from the diet (i.e., fermentation of dietary fibers and resistant starch); (2) metabolism of xenobiotics, both potentially beneficial or detrimental (i.e., dietary constituents, drugs, carcinogens, etc.); (3) renewal of gut epithelial cells and maintenance of mucosal integrity; and (4) affecting immune system development and activity. Understanding the complex and dynamic interplay between the gut microbiome, host immune system, and dietary exposures may help elucidate mechanisms for carcinogenesis and guide future cancer prevention and treatment strategies.
datePublished:2014
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