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Title:
Toll-Like Receptors (TLRs) and Their Ligands | SpringerLink
Description:
The innate immune system is an evolutionally conserved host defense mechanism against pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs), which recognize microbial components that are essential for the survival of the...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Netea MG, van Deuren M, Kullberg BJ, Cavaillon JM, Van der Meer JW (2002b) Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?

Schema {🗺️}

ScholarlyArticle:
      headline:Toll-Like Receptors (TLRs) and Their Ligands
      pageEnd:20
      pageStart:1
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-540-72167-3.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Toll-Like Receptors (TLRs) and Innate Immunity
         isbn:
            978-3-540-72167-3
            978-3-540-72166-6
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
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      author:
            name:Satoshi Uematsu
            affiliation:
            type:Person
            name:Shizuo Akira
            affiliation:
                  name:Osaka University
                  address:
                     name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Respiratory Syncytial Virus, West Nile Virus, Cerebral Malaria, Trypanosoma Cruzi, Toll Pathway
      description:The innate immune system is an evolutionally conserved host defense mechanism against pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs), which recognize microbial components that are essential for the survival of the microorganism. PRRs are germline-encoded, nonclonal, and expressed constitutively in the host. Different PRRs react with specific ligands and lead to distinct antipathogen responses. Among them, Toll-like receptors (TLRs) are capable of sensing organisms ranging from bacteria to fungi, protozoa, and viruses, and they play a major role in innate immunity. Here, we review the mechanism of pathogen recognition by TLRs.
      datePublished:2008
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Book:
      name:Toll-Like Receptors (TLRs) and Innate Immunity
      isbn:
         978-3-540-72167-3
         978-3-540-72166-6
Organization:
      name:Springer Berlin Heidelberg
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         type:ImageObject
      name:Osaka University
      address:
         name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
         type:PostalAddress
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Person:
      name:Satoshi Uematsu
      affiliation:
      name:Shizuo Akira
      affiliation:
            name:Osaka University
            address:
               name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
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