We are analyzing https://link.springer.com/chapter/10.1007/978-3-540-68976-8_12.

Title:
The Participation of Mesenchymal Stem Cells in Tumor Stroma Formation and Their Application as Targeted-Gene Delivery Vehicles | SpringerLink
Description:
Recent evidence suggests that mesenchymal stem cells (MSC) selectively proliferate to tumors and contribute to the formation of tumor-associated stroma. The biological rationale for tumor recruitment of MSC remains unclear but may represent an effort of the host to...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Bissell MJ, Labarge MA (2005) Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?
Harrington K, Alvarez-Vallina L, Crittenden M, et al (2002) Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?
Kunz-Schughart LA, Knuechel R (2002a) Tumor-associated fibroblasts (part I): active stromal participants in tumor development and progression?
Rowley DR (1998) What might a stromal response mean to prostate cancer progression?

Schema {🗺️}

ScholarlyArticle:
      headline:The Participation of Mesenchymal Stem Cells in Tumor Stroma Formation and Their Application as Targeted-Gene Delivery Vehicles
      pageEnd:283
      pageStart:263
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-540-68976-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Bone Marrow-Derived Progenitors
         isbn:
            978-3-540-68976-8
            978-3-540-68975-1
         type:Book
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:B. Hall
            affiliation:
                  name:Columbus Children’s Research Institute
                  address:
                     name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Andreeff
            affiliation:
                  name:The University of Texas M. D. Anderson Cancer Center
                  address:
                     name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:F. Marini
            affiliation:
                  name:The University of Texas M. D. Anderson Cancer Center
                  address:
                     name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Mesenchymal Stem Cell (MSC), Tumor Microenvironment, Tumor-associated Fibroblast (TAF), Stromagenesis, Myofibroblast, Desmoplasia, Tumor Stroma
      description:Recent evidence suggests that mesenchymal stem cells (MSC) selectively proliferate to tumors and contribute to the formation of tumor-associated stroma. The biological rationale for tumor recruitment of MSC remains unclear but may represent an effort of the host to blunt tumor cell growth and improve survival. There is mounting experimental evidence that normal stromal cells can revert malignant cell behavior, and separate studies have demonstrated that stromal cells can enhance tumor progression after acquisition of tumor-like genetic lesions. Together, these observations support the rationale for modifying normal MSC to deliver therapeutic proteins directly into the tumor microenvironment. Modified MSC can produce high concentrations of antitumor proteins directly within the Tumor mass, which have been shown to blunt tumor growth kinetics in experimental animal model systems. In this chapter we will address the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.
      datePublished:2007
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      name:Bone Marrow-Derived Progenitors
      isbn:
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         978-3-540-68975-1
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      name:Springer Berlin Heidelberg
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Columbus Children’s Research Institute
      address:
         name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
         type:PostalAddress
      name:The University of Texas M. D. Anderson Cancer Center
      address:
         name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas M. D. Anderson Cancer Center
      address:
         name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
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      affiliation:
            name:Columbus Children’s Research Institute
            address:
               name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
               type:PostalAddress
            type:Organization
      name:M. Andreeff
      affiliation:
            name:The University of Texas M. D. Anderson Cancer Center
            address:
               name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:F. Marini
      affiliation:
            name:The University of Texas M. D. Anderson Cancer Center
            address:
               name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Center for Childhood Cancer, Columbus Children’s Research Institute, Columbus, USA
      name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
      name:Department of Blood and Marrow Transplantation, Unit 81, The University of Texas M. D. Anderson Cancer Center, Houston, USA
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