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Title:
Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model | SpringerLink
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HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce...
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article, google, scholar, cancer, pubmed, central, hepatocellular, cas, carcinoma, liver, szabo, alcohol, disease, model, gastroenterol, mouse, chapter, privacy, cookies, content, information, publish, paper, alcoholic, hcc, usa, springer, search, accelerates, early, inflammation, micrornas, hepatol, download, university, usd, personal, data, log, journal, research, conference, gyongyi, book, medicine, chronic, hepatitis, access, hepatic, satishchandran,
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mir-122-mediated hif-1alpha activation month download article/chapter including epithelial-mesenchymal transition neurotensin/interleukin-8/cxcl1 signaling alcoholic liver disease alcoholic liver disease conference paper alcohol device instant download privacy choices/manage cookies global cancer statistics promote hcc development massachusetts medical school molecular hepatic carcinogenesis human hepatocellular carcinoma hepatocellular carcinoma arising liver disease european economic area sex-dependent manner diet-induced steatohepatitis cirrhotic nonalcoholic steatohepatitis current antiviral therapy author information authors editor information editors conditions privacy policy liver cancer accepting optional cookies il-17re associate environmental health sciences adult mouse model main content log paper szabo chapter usd 29 journal finder publish cancer res 67 disease burden paper cite chronic hepatitis tang zy permissions reprints liver int 35 hepatocellular carcinoma gyongyi szabo chapter log ca cancer privacy policy check access ethics access mir-122a microrna frequently macrophage activation
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ScholarlyArticle:
headline:Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model
pageEnd:79
pageStart:71
image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-98788-0.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Alcohol and Cancer
isbn:
978-3-319-98788-0
978-3-319-98787-3
type:Book
publisher:
name:Springer International Publishing
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Gyongyi Szabo
affiliation:
name:University of Massachusetts Medical School
address:
name:Department of Medicine, University of Massachusetts Medical School, Worcester, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Inflammation, miR-122, DEN, Macrophage polarization, Neutrophil leukocyte, Biliary cyst, Alpha fetoprotein, Stemness, Hypoxia-inducible factor-1alpha
description:HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce HCC, however, it can promote HCC development after a carcinogen exposure. Multiple mechanisms are involved in carcinogenesis and alcohol affects many of those including epithelial-mesenchymal transition, cancer stem marker expression and inflammation as evidenced in our HCC model.
datePublished:2018
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affiliation:
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address:
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