We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-42044-8_7.

Title:
Liquid Profiling in Lung Cancer – Quantification of Extracellular miRNAs in Bronchial Lavage | SpringerLink
Description:
Extracellular miRNAs cannot only be isolated from different body fluids like plasma and serum, but also from bronchial lavage samples (BL) obtained by bronchoscopy. Alterations in the expression of microRNAs might be useful for a discrimination of lung cancer...
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Keywords {🔍}

cancer, lung, article, pubmed, google, scholar, microrna, cas, plasma, micrornas, patients, mirnas, lavage, schmidt, fleischhacker, privacy, cookies, content, information, publish, circulating, paper, author, chapter, springer, data, search, serum, profiling, extracellular, bronchial, bernd, michael, expression, biomarkers, access, download, klinik, innere, medizin, schwerpunkt, pneumologie, germany, usd, personal, log, journal, research, nucleic, acids,

Topics {✒️}

month download article/chapter reduced lung-cancer mortality small-cell lung cancer circulating nucleic acids michael fleischhacker privacy choices/manage cookies schwerpunkt pneumologie microrna expression profiling lung cancer detection device instant download author contributed equally european economic area lung cancer diagnosis editor information editors liquid profiling benign lung disease bronchial lavage samples conserved seed pairing generation biomarker breakthrough walter schulz stiftung microrna quality control plasma/bronchoalveolar lavage hsa-mir 19b-1 conditions privacy policy tuberc respir dis berlin lung cancer patients bronchoalveolar lavage fluid accepting optional cookies main content log profiled extracellular micrornas check access promising tumor biomarkers ethics access rehbein journal finder publish paper schmidt chapter usd 29 permissions reprints paper cite lung cancer bronchial lavage hsa-mir 1285 author correspondence circulating micrornas privacy policy extracellular mirnas financial support chapter log books a

Schema {🗺️}

ScholarlyArticle:
      headline:Liquid Profiling in Lung Cancer – Quantification of Extracellular miRNAs in Bronchial Lavage
      pageEnd:37
      pageStart:33
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-42044-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Circulating Nucleic Acids in Serum and Plasma – CNAPS IX
         isbn:
            978-3-319-42044-8
            978-3-319-42042-4
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Bernd Schmidt
            affiliation:
                  name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
                  address:
                     name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
                     type:PostalAddress
                  type:Organization
                  name:Klinik für Innere Medizin – Schwerpunkt Pneumologie und Schlafmedizin DRK Kliniken Berlin∣Mitte
                  address:
                     name:Klinik für Innere Medizin – Schwerpunkt Pneumologie und Schlafmedizin DRK Kliniken Berlin∣Mitte, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Grit Rehbein
            affiliation:
                  name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
                  address:
                     name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Fleischhacker
            affiliation:
                  name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
                  address:
                     name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Bronchial lavage, miRNA, Real-time PCR, Lung cancer, Detection
      description:Extracellular miRNAs cannot only be isolated from different body fluids like plasma and serum, but also from bronchial lavage samples (BL) obtained by bronchoscopy. Alterations in the expression of microRNAs might be useful for a discrimination of lung cancer patients from patients with a benign lung disease. We profiled extracellular microRNAs from three BL pools of lung cancer patients and three BL pools from a control group (patients with a benign lung disease) with TaqMan MicroRNA Array cards. For the confirmation of these results, we analyzed a panel of eight miRNAs in a qRT-PCR of the BL of 30 different lung cancer and non-cancerous patients. For the data normalization, we used exogenously added cel-miR-39 RNA. Using microRNA arrays, we found a panel of eight microRNAs (hsa-miR 19b-1, 1285, 1289, 1303, 217, 29a-5p, 548-3p, 650) that were differentially expressed between the lung cancer and the non-cancerous group. Further investigation by qPCR revealed five microRNAs (U6 snRNA, hsa-miR 1285, 1303, 29a-5p, 650) that were significantly up-regulated in patients with lung cancer. In bronchial lavage samples, the five microRNAs identified in this study may have a diagnostic potential to be used as biomarkers in lung cancer.
      datePublished:2016
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Circulating Nucleic Acids in Serum and Plasma – CNAPS IX
      isbn:
         978-3-319-42044-8
         978-3-319-42042-4
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
      address:
         name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
         type:PostalAddress
      name:Klinik für Innere Medizin – Schwerpunkt Pneumologie und Schlafmedizin DRK Kliniken Berlin∣Mitte
      address:
         name:Klinik für Innere Medizin – Schwerpunkt Pneumologie und Schlafmedizin DRK Kliniken Berlin∣Mitte, Berlin, Germany
         type:PostalAddress
      name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
      address:
         name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
         type:PostalAddress
      name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
      address:
         name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Bernd Schmidt
      affiliation:
            name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
            address:
               name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
               type:PostalAddress
            type:Organization
            name:Klinik für Innere Medizin – Schwerpunkt Pneumologie und Schlafmedizin DRK Kliniken Berlin∣Mitte
            address:
               name:Klinik für Innere Medizin – Schwerpunkt Pneumologie und Schlafmedizin DRK Kliniken Berlin∣Mitte, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Grit Rehbein
      affiliation:
            name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
            address:
               name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
               type:PostalAddress
            type:Organization
      name:Michael Fleischhacker
      affiliation:
            name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie
            address:
               name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
      name:Klinik für Innere Medizin – Schwerpunkt Pneumologie und Schlafmedizin DRK Kliniken Berlin∣Mitte, Berlin, Germany
      name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
      name:Universitätsklinikum Halle (Saale), Klinik für Innere Medizin, Schwerpunkt Pneumologie, Halle/Saale, Germany
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

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