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Title:
Inflammasome Recognition and Regulation of the Legionella Flagellum | SpringerLink
Description:
The Gram-negative bacterium Legionella pneumophila colonizes extracellular environmental niches and infects free-living protozoa. Upon inhalation into the human lung, the opportunistic pathogen grows in macrophages and causes a fulminant pneumonia termed...
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Schema {🗺️}

ScholarlyArticle:
      headline:Inflammasome Recognition and Regulation of the Legionella Flagellum
      pageEnd:181
      pageStart:161
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-41171-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Inflammasome Signaling and Bacterial Infections
         isbn:
            978-3-319-41171-2
            978-3-319-41170-5
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ursula Schell
            affiliation:
                  name:Ludwig-Maximilians University
                  address:
                     name:Max von Pettenkofer Institute, Ludwig-Maximilians University, Munich, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sylvia Simon
            affiliation:
                  name:University of Zürich
                  address:
                     name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hubert Hilbi
            affiliation:
                  name:University of Zürich
                  address:
                     name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Amoeba, Autoinducer, Dictyostelium , Effector protein, Flagellin, Macrophage, NAIP5/NLRC4 inflammasome, Pathogen vacuole, Phosphoinositide, Small GTPase, Type IV secretion, Quorum sensing
      description:The Gram-negative bacterium Legionella pneumophila colonizes extracellular environmental niches and infects free-living protozoa. Upon inhalation into the human lung, the opportunistic pathogen grows in macrophages and causes a fulminant pneumonia termed Legionnaires’ disease. L. pneumophila employs a biphasic life cycle, comprising a replicative, non-virulent, and a stationary, virulent form. In the latter phase, the pathogen produces a plethora of so-called effector proteins, which are injected into host cells, where they subvert pivotal processes and promote the formation of a distinct membrane-bound compartment, the Legionella-containing vacuole. In the stationary phase, the bacteria also produce a single monopolar flagellum and become motile. L. pneumophila flagellin is recognized by and triggers the host’s NAIP5 (Birc1e)/NLRC4 (Ipaf) inflammasome, which leads to caspase-1 activation, pore formation, and pyroptosis. The production of L. pneumophila flagellin and pathogen–host interactions are controlled by a complex stationary phase regulatory network, detecting nutrient availability as well as the Legionella quorum sensing (Lqs) signaling compound LAI-1 (3-hydroxypentadecane-4-one). Thus, the small molecule LAI-1 coordinates L. pneumophila flagellin production and motility, inflammasome activation, and virulence.
      datePublished:2016
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Book:
      name:Inflammasome Signaling and Bacterial Infections
      isbn:
         978-3-319-41171-2
         978-3-319-41170-5
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Ludwig-Maximilians University
      address:
         name:Max von Pettenkofer Institute, Ludwig-Maximilians University, Munich, Germany
         type:PostalAddress
      name:University of Zürich
      address:
         name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
         type:PostalAddress
      name:University of Zürich
      address:
         name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ursula Schell
      affiliation:
            name:Ludwig-Maximilians University
            address:
               name:Max von Pettenkofer Institute, Ludwig-Maximilians University, Munich, Germany
               type:PostalAddress
            type:Organization
      name:Sylvia Simon
      affiliation:
            name:University of Zürich
            address:
               name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
               type:PostalAddress
            type:Organization
      name:Hubert Hilbi
      affiliation:
            name:University of Zürich
            address:
               name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Max von Pettenkofer Institute, Ludwig-Maximilians University, Munich, Germany
      name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
      name:Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
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