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Title:
Sonodynamic Therapy: Concept, Mechanism and Application to Cancer Treatment | SpringerLink
Description:
Sonodynamic therapy (SDT) represents an emerging approach that offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. It involves the sensitization of target tissues with a non-toxic sensitizing chemical agent and subsequent...
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ScholarlyArticle:
      headline:Sonodynamic Therapy: Concept, Mechanism and Application to Cancer Treatment
      pageEnd:450
      pageStart:429
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-22536-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Therapeutic Ultrasound
         isbn:
            978-3-319-22536-4
            978-3-319-22535-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Anthony P. McHale
            affiliation:
                  name:University of Ulster
                  address:
                     name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John F. Callan
            affiliation:
                  name:University of Ulster
                  address:
                     name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Nikolitsa Nomikou
            affiliation:
                  name:University College London
                  address:
                     name:Division of Surgery and Interventional Science, University College London, London, England, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Colin Fowley
            affiliation:
                  name:University of Ulster
                  address:
                     name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bridgeen Callan
            affiliation:
                  name:University of Ulster
                  address:
                     name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Sonodynamic therapy, Ultrasound, Sonosensitizer, Reactive oxygen species, Cancer
      description:Sonodynamic therapy (SDT) represents an emerging approach that offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. It involves the sensitization of target tissues with a non-toxic sensitizing chemical agent and subsequent exposure of the sensitized tissues to relatively low-intensity ultrasound. Essentially, both aspects (the sensitization and ultrasound exposure) are harmless, and cytotoxic events occur when both are combined. Due to the significant depth that ultrasound penetrates tissue, the approach provides an advantage over similar alternative approaches, such as photodynamic therapy (PDT), in which less penetrating light is employed to provide the cytotoxic effect in sensitized tissues. This suggests that sonodynamic therapy may find wider clinical application, particularly for the non-invasive treatment of less accessible lesions. Early SDT-based approaches employed many of the sensitizers used in PDT, although the manner in which ultrasound activates the sensitizer differs from activation events in PDT. Here we will review the currently accepted mechanisms by which ultrasound activates sensitizers to elicit cytotoxic effects. In addition, we will explore the breath of evidence from in-vitro and in-vivo SDT-based studies, providing the reader with an insight into the therapeutic potential offered by SDT in the treatment of cancer.
      datePublished:2016
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      isbn:
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         978-3-319-22535-7
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      name:Springer International Publishing
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      name:University of Ulster
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         name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
         type:PostalAddress
      name:University of Ulster
      address:
         name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
         type:PostalAddress
      name:University College London
      address:
         name:Division of Surgery and Interventional Science, University College London, London, England, UK
         type:PostalAddress
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      address:
         name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
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         name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
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      name:Anthony P. McHale
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            address:
               name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
               type:PostalAddress
            type:Organization
      name:John F. Callan
      affiliation:
            name:University of Ulster
            address:
               name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Nikolitsa Nomikou
      affiliation:
            name:University College London
            address:
               name:Division of Surgery and Interventional Science, University College London, London, England, UK
               type:PostalAddress
            type:Organization
      name:Colin Fowley
      affiliation:
            name:University of Ulster
            address:
               name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
               type:PostalAddress
            type:Organization
      name:Bridgeen Callan
      affiliation:
            name:University of Ulster
            address:
               name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
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      name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
      name:Division of Surgery and Interventional Science, University College London, London, England, UK
      name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
      name:School of Pharmacy and Pharmaceutical Sciences, University of Ulster, Coleraine, Co. Derry, UK
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