We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-20149-8_12.

Title:
Perforins | SpringerLink
Description:
“Perforins” – cytotoxic cell perforin-1, proteins contributing to the complement membrane attack complex (MAC) and other perforin-like proteins – form unconventional pores in biological membranes in the sense that as well as a ring of subunits...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Teissie J, Golzio M, Rols MP (2005) Mechanisms of cell membrane electropermeabilization: a minireview of our present (lack of ?

Schema {🗺️}

ScholarlyArticle:
      headline:Perforins
      pageEnd:312
      pageStart:289
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-20149-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Electrophysiology of Unconventional Channels and Pores
         isbn:
            978-3-319-20149-8
            978-3-319-20148-1
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Robert J. C. Gilbert
            affiliation:
                  name:Wellcome Trust Centre for Human Genetics, University of Oxford
                  address:
                     name:Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Perforin, Complement membrane attack complex, Toroidal pore, Proteolipidic pore, Single channel conductance
      description:“Perforins” – cytotoxic cell perforin-1, proteins contributing to the complement membrane attack complex (MAC) and other perforin-like proteins – form unconventional pores in biological membranes in the sense that as well as a ring of subunits circumscribing an opening in the lipid bilayer, arcs of subunits induce similar effects. The resulting arc-pore structures are completed by a lipidic edge, conferring distinctive functional characteristics on them. Electrophysiological measurements have played a distinguished role in the discovery and characterisation of this alternative mechanism of pore formation which enables the same protein to form widely-varying sizes of pore and enact a greater diversity of effects than more conventional channels. This review discusses the mechanism of pore formation by the perforins and the way in which it has been illuminated by electrical conductance studies alongside imaging methods such as electron microscopy and atomic force microscopy.
      datePublished:2015
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Book:
      name:Electrophysiology of Unconventional Channels and Pores
      isbn:
         978-3-319-20149-8
         978-3-319-20148-1
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      name:Springer International Publishing
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      name:Wellcome Trust Centre for Human Genetics, University of Oxford
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      name:Robert J. C. Gilbert
      affiliation:
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            address:
               name:Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
               type:PostalAddress
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      email:[email protected]
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      name:Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
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