We are analyzing https://link.springer.com/chapter/10.1007/978-3-319-04843-7_2.

Title:
Wnt Signaling in Osteosarcoma | SpringerLink
Description:
Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children and adolescents with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

Luo J et al (2007) Wnt signaling and human diseases: what are the therapeutic implications?
Takahashi-Yanaga F, Kahn M (2010) Targeting Wnt signaling: can we safely eradicate cancer stem cells?

Schema {🗺️}

ScholarlyArticle:
      headline:Wnt Signaling in Osteosarcoma
      pageEnd:45
      pageStart:33
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-04843-7.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Current Advances in Osteosarcoma
         isbn:
            978-3-319-04843-7
            978-3-319-04842-0
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Carol H. Lin
            affiliation:
                  name:CHOC Children’s Hospital
                  address:
                     name:The Hyundai Cancer Institute, CHOC Children’s Hospital, Orange, USA
                     type:PostalAddress
                  type:Organization
                  name:University of California
                  address:
                     name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tao Ji
            affiliation:
                  name:University of California
                  address:
                     name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
                     type:PostalAddress
                  type:Organization
                  name:Peking University
                  address:
                     name:Musculoskeletal Tumor Center, People’s Hospital, Peking University, Beijing, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cheng-Fong Chen
            affiliation:
                  name:University of California
                  address:
                     name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
                     type:PostalAddress
                  type:Organization
                  name:Taipei Veterans General Hospital
                  address:
                     name:Department of Orthopaedics, Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bang H. Hoang
            affiliation:
                  name:University of California
                  address:
                     name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Osteosarcoma, Wnt, β-Catenin, Dickkopf, Wnt inhibitory protein, Frizzled-related proteins
      description:Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children and adolescents with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis within the last two decades. With current treatments, 60–70 % of patients with localized disease survive. Given a propensity of Wnt signaling to control multiple cellular processes, including proliferation, cell fate determination, and differentiation, it is a critical pathway in OS disease progression. At the same time, this pathway is extremely complex with vast arrays of cross-talk. Even though decades of research have linked the role of Wnt to tumorigenesis, there are still outstanding areas that remain poorly understood and even controversial. The canonical Wnt pathway functions to regulate the levels of the transcriptional co-activator β-catenin, which ultimately controls key developmental gene expressions. Given the central role of this mediator, inhibition of Wnt/β-catenin signaling has been investigated as a potential strategy for cancer control. In OS, several secreted protein families modulate the Wnt/β-catenin signaling, including secreted Frizzled-related proteins (sFRPs), Wnt inhibitory protein (WIF), Dickkopf proteins (DKK-1,2,3), sclerostin, and small molecules. This chapter focuses on our current understanding of Wnt/β-catenin signaling in OS, based on recent in vitro and in vivo data. Wnt activates noncanonical signaling pathways as well that are independent of β-catenin which will be discussed. In addition, stem cells and their association with Wnt/β-catenin are important factors to consider. Ultimately, the multiple canonical and noncanonical Wnt/β-catenin agonists and antagonists need to be further explored for potential targeted therapies.
      datePublished:2014
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Book:
      name:Current Advances in Osteosarcoma
      isbn:
         978-3-319-04843-7
         978-3-319-04842-0
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:CHOC Children’s Hospital
      address:
         name:The Hyundai Cancer Institute, CHOC Children’s Hospital, Orange, USA
         type:PostalAddress
      name:University of California
      address:
         name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
         type:PostalAddress
      name:University of California
      address:
         name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
         type:PostalAddress
      name:Peking University
      address:
         name:Musculoskeletal Tumor Center, People’s Hospital, Peking University, Beijing, People’s Republic of China
         type:PostalAddress
      name:University of California
      address:
         name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
         type:PostalAddress
      name:Taipei Veterans General Hospital
      address:
         name:Department of Orthopaedics, Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan
         type:PostalAddress
      name:University of California
      address:
         name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Carol H. Lin
      affiliation:
            name:CHOC Children’s Hospital
            address:
               name:The Hyundai Cancer Institute, CHOC Children’s Hospital, Orange, USA
               type:PostalAddress
            type:Organization
            name:University of California
            address:
               name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
               type:PostalAddress
            type:Organization
      name:Tao Ji
      affiliation:
            name:University of California
            address:
               name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
               type:PostalAddress
            type:Organization
            name:Peking University
            address:
               name:Musculoskeletal Tumor Center, People’s Hospital, Peking University, Beijing, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Cheng-Fong Chen
      affiliation:
            name:University of California
            address:
               name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
               type:PostalAddress
            type:Organization
            name:Taipei Veterans General Hospital
            address:
               name:Department of Orthopaedics, Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan
               type:PostalAddress
            type:Organization
      name:Bang H. Hoang
      affiliation:
            name:University of California
            address:
               name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Hyundai Cancer Institute, CHOC Children’s Hospital, Orange, USA
      name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
      name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
      name:Musculoskeletal Tumor Center, People’s Hospital, Peking University, Beijing, People’s Republic of China
      name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
      name:Department of Orthopaedics, Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan
      name:Department of Orthopaedic Surgery and Chao Family Comprehensive Cancer Center, University of California, Orange, USA
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