We are analyzing https://link.springer.com/protocol/10.1007/978-1-61779-316-5_22.

Title:
Inhibition of Histone Deacetylases | SpringerLink
Description:
Lysine acetylation of histones is one of the major epigenetic regulators of chromatin conformation and gene expression. The dynamic nature of histone acetylation is determined by the counterbalancing activity of histone acetyltransferase and histone deacetylase...
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

google, scholar, pubmed, article, cas, histone, cancer, deacetylase, biol, davidson, methods, inhibitors, chromatin, hdac, inhibition, acetylation, cells, protocol, genes, chem, breast, mol, nat, cell, human, privacy, cookies, content, information, publish, research, deacetylases, expression, activity, access, res, estrogen, chipchip, analysis, data, search, epigenetics, protocols, huang, shaw, lysine, histones, epigenetic, nature, open,

Topics {✒️}

month download article/chapter hdac inhibitor-based therapies silac-based proteomic analysis estrogen receptor alpha cutaneous t-cell lymphomas cutaneous t-cell lymphoma aberrantly silenced genes histone deacetylase inhibitor chip-chip data analysis epigenetics protocols histone deacetylase inhibitors lysine-specific demethylase 1 privacy choices/manage cookies lysine acetylation revealed device instant download mammalian histone deacetylase chip-chip molecular methods cultured mammalian cells human hdac7 harbors support vector machines humana press histone deacetylases inhibitors histone deacetylases protocol histone deacetylase inhibition journal finder publish cancer therapy cryptic deacetylase activity protein phosphatase 2a combinatorial histone codes protein-dna interaction breast cancer res tumor-selective action genome-wide analysis unknown target genes european economic area recent technological developments high throughput characterization genome-wide mapping human transcription factors polyamine analogues results author information authors editor information editors ii histone deacetylases dna microarray hybridization conditions privacy policy major epigenetic regulators transcriptionally active chromatin structure-activity relationships promoter dna hypermethylation nucleic acids res

Schema {🗺️}

ScholarlyArticle:
      headline:Inhibition of Histone Deacetylases
      pageEnd:311
      pageStart:297
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-61779-316-5.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Epigenetics Protocols
         isbn:
            978-1-61779-316-5
            978-1-61779-315-8
         type:Book
      publisher:
         name:Humana Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yi Huang
            affiliation:
                  name:University of Pittsburgh Cancer Institute
                  address:
                     name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Patrick G. Shaw
            affiliation:
                  name:University of Pittsburgh Cancer Institute
                  address:
                     name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nancy E. Davidson
            affiliation:
                  name:University of Pittsburgh Cancer Institute
                  address:
                     name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Histone deacetylases, Histone acetyltransferases, HDAC inhibitors, Epigenetic gene silencing, Chromatin remodeling
      description:Lysine acetylation of histones is one of the major epigenetic regulators of chromatin conformation and gene expression. The dynamic nature of histone acetylation is determined by the counterbalancing activity of histone acetyltransferase and histone deacetylase (HDAC) enzymes. Acetylation of histones is generally associated with open and transcriptionally active chromatin, whereas the activity of HDACs leads to histone deacetylation, condensation of chromatin, and inhibition of transcription. Aberrant silencing of tumor suppressors and other genes has been found in different types of cancer. Abnormal activity of HDACs has been implicated in tumorigenesis and therefore considerable effort has been put into the development of HDAC inhibitors as a means of modifying histone acetylation status and reexpressing aberrantly silenced tumor suppressor genes. This has led to the generation of a number of structurally diverse compounds that can effectively inhibit HDAC activity, thus altering chromatin structure in cancer cells. This unit discusses the methods and recent technological developments with respect to the studies of HDAC inhibition in cancer.
      datePublished:2011
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Epigenetics Protocols
      isbn:
         978-1-61779-316-5
         978-1-61779-315-8
Organization:
      name:Humana Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Pittsburgh Cancer Institute
      address:
         name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
         type:PostalAddress
      name:University of Pittsburgh Cancer Institute
      address:
         name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
         type:PostalAddress
      name:University of Pittsburgh Cancer Institute
      address:
         name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yi Huang
      affiliation:
            name:University of Pittsburgh Cancer Institute
            address:
               name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Patrick G. Shaw
      affiliation:
            name:University of Pittsburgh Cancer Institute
            address:
               name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Nancy E. Davidson
      affiliation:
            name:University of Pittsburgh Cancer Institute
            address:
               name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
      name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
      name:University of Pittsburgh Cancer Institute, Pittsburgh, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(136)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js

CDN Services {📦}

Pbgrd

5.42s.

LINK . SPRINGER . COM {}