We are analyzing https://link.springer.com/protocol/10.1007/978-1-60761-753-2_16.

Title:
Engineered Zinc Finger Proteins for Manipulation of the Human Mitochondrial Genome | SpringerLink
Description:
Currently there are no effective methods to manipulate or modify particular sequences in mammalian mitochondrial DNA (mtDNA) within cells. The availability of such methods would be of great value for basic mitochondrial research and would aid in development of...
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

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Questions {❓}

(2008) What causes mitochondrial DNA deletions in human cells?

Schema {🗺️}

ScholarlyArticle:
      headline:Engineered Zinc Finger Proteins for Manipulation of the Human Mitochondrial Genome
      pageEnd:270
      pageStart:257
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-60761-753-2.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Engineered Zinc Finger Proteins
         isbn:
            978-1-60761-753-2
            978-1-60761-752-5
         type:Book
      publisher:
         name:Humana Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michal Minczuk
            affiliation:
                  name:Medical Research Council Mitochondrial Biology Unit
                  address:
                     name:Medical Research Council Mitochondrial Biology Unit, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Mitochondrial import, nuclear export signal, mitochondrial diseases, gene therapy, engineered zinc fingers, zinc finger nuclease
      description:Currently there are no effective methods to manipulate or modify particular sequences in mammalian mitochondrial DNA (mtDNA) within cells. The availability of such methods would be of great value for basic mitochondrial research and would aid in development of therapies for diseases linked with mutations in mtDNA. Engineered zinc finger proteins have been used as powerful tools for intervening in nuclear gene expression and modifying nuclear DNA in a sequence-specific manner. Here, basic methods that are helpful in adapting the engineered zinc finger technology for targeting the DNA in mitochondria are presented with the main emphasis on mitochondrial import of zinc finger proteins.
      datePublished:2010
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Book:
      name:Engineered Zinc Finger Proteins
      isbn:
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         978-1-60761-752-5
Organization:
      name:Humana Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical Research Council Mitochondrial Biology Unit
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Person:
      name:Michal Minczuk
      affiliation:
            name:Medical Research Council Mitochondrial Biology Unit
            address:
               name:Medical Research Council Mitochondrial Biology Unit, Cambridge, UK
               type:PostalAddress
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