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Title:
Essentials of Recombinase-Based Genetic Fate Mapping in Mice | SpringerLink
Description:
Fate maps, by defining the relationship between embryonic tissue organization and postnatal tissue structure, are one of the most important tools on hand to developmental biologists. In the past, generating such maps in mice was hindered by their in utero development...
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Keywords {🔍}

pubmed, google, scholar, article, cas, mouse, genetic, fate, cell, sitespecific, mice, dymecki, recombination, gene, recombinase, cre, mapping, neuron, expression, biol, analysis, development, cells, proc, natl, acad, sci, res, protocol, jensen, lineage, nat, neural, dev, system, genesis, research, molecular, methods, nature, privacy, cookies, content, information, publish, embryonic, access, recombinases, intersectional, lineages,

Topics {✒️}

temporally-controlled site-specific mutagenesis ligand-regulated site-specific recombination ligand-activated site-specific recombination month download article/chapter yeast site-specific recombinase apical ectodermal ridge phic31 site-specific recombination applied site-specific recombination wnt1-expressing neural progenitors recombinase-based intersectional strategies conditional site-specific recombination cell type-specific manner site-specific recombination system cell-heritable reporter transgene high-throughput cre reporting mouse midbrain-hindbrain constriction mouse molecular embryology flp-dependent lineage analysis tamoxifen-inducible cre-er site-specific recombinases receptor alpha mediated stem cell research site-specific integration research triangle park ligand-activated flpe flp-mediated recombination privacy choices/manage cookies device instant download generate embryonic mosaics genetic fate mapping manipulating single neurons tamoxifen-inducible form high-efficiency flp mapping cell fate tracing cell lineages adult mouse brain inducible mouse mutants p1 recombinase cre recombining site loxp high-expression transfectants establishing genetic lineages conditional gene traps flp recombinase evolved hindbrain rhombic lip conditional floxed alleles intersectional gene activation european economic area postnatal tissue structure bacterial artificial chromosomes situ hybridization database

Schema {🗺️}

ScholarlyArticle:
      headline:Essentials of Recombinase-Based Genetic Fate Mapping in Mice
      pageEnd:454
      pageStart:437
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-60327-292-6.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Mouse Molecular Embryology
         isbn:
            978-1-60327-292-6
            978-1-60327-290-2
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Patricia Jensen
            affiliation:
                  name:National Institute of Environmental Health Sciences, National Institute of Health
                  address:
                     name:Laboratory of Neurobiology, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Susan M. Dymecki
            affiliation:
                  name:Harvard Medical School
                  address:
                     name:Department of Genetics, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Fate map, Cre, Flp, Substractive genetic fate mapping, Intersectional genetic fate mapping, Genetic inducible fate mapping
      description:Fate maps, by defining the relationship between embryonic tissue organization and postnatal tissue structure, are one of the most important tools on hand to developmental biologists. In the past, generating such maps in mice was hindered by their in utero development limiting the physical access required for traditional methods involving tracer injection or cell transplantation. No longer is physical access a requirement. Innovations over the past decade have led to genetic techniques that offer means to “deliver” cell lineage tracers noninvasively. Such “genetic fate mapping” approaches employ transgenic strategies to express genetically encoded site-specific recombinases in a cell type-specific manner to switch on expression of a cell-heritable reporter transgene as lineage tracer. The behaviors and fate of marked cells and their progeny can then be explored and their contributions to different tissues examined. Here, we review the basic concepts of genetic fate mapping and consider the strengths and limitations for their application. We also explore two refinements of this approach that lend improved spatial and temporal resolution: (1) Intersectional and subtractive genetic fate mapping and (2) Genetic inducible fate mapping.
      datePublished:2014
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Book:
      name:Mouse Molecular Embryology
      isbn:
         978-1-60327-292-6
         978-1-60327-290-2
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Institute of Environmental Health Sciences, National Institute of Health
      address:
         name:Laboratory of Neurobiology, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, USA
         type:PostalAddress
      name:Harvard Medical School
      address:
         name:Department of Genetics, Harvard Medical School, Boston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Patricia Jensen
      affiliation:
            name:National Institute of Environmental Health Sciences, National Institute of Health
            address:
               name:Laboratory of Neurobiology, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, USA
               type:PostalAddress
            type:Organization
      name:Susan M. Dymecki
      affiliation:
            name:Harvard Medical School
            address:
               name:Department of Genetics, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Laboratory of Neurobiology, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, USA
      name:Department of Genetics, Harvard Medical School, Boston, USA
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