We are analyzing https://link.springer.com/protocol/10.1007/978-1-59745-232-8_7.

Title:
Transposon-Mediated Mutagenesis in Somatic Cells | SpringerLink
Description:
Understanding the genetic basis for tumor formation is crucial for treating cancer. Forward genetic screens using insertional mutagenesis technologies have identified many important tumor suppressor genes and oncogenes in mouse models of human cancer. Traditionally,...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

(2002) Retroviral insertion sites and cancer: fountain of all knowledge?

Schema {🗺️}

ScholarlyArticle:
      headline:Transposon-Mediated Mutagenesis in Somatic Cells
      pageEnd:108
      pageStart:95
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-59745-232-8.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Chromosomal Mutagenesis
         isbn:
            978-1-59745-232-8
            978-1-58829-899-7
         type:Book
      publisher:
         name:Humana Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:David A. Largaespada
            affiliation:
                  name:University of Minnesota
                  address:
                     name:Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lara S. Collier
            affiliation:
                  name:University of Minnesota
                  address:
                     name:Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Cancer genetics, linker-mediated PCR, mouse transgenesis, Sleeping Beauty, somatic mutagenesis, transposon
      description:Understanding the genetic basis for tumor formation is crucial for treating cancer. Forward genetic screens using insertional mutagenesis technologies have identified many important tumor suppressor genes and oncogenes in mouse models of human cancer. Traditionally, retroviruses have been used for this purpose, allowing the identification of genes that can cause various forms of leukemia or lymphoma with murine leukemia viruses or mammary cancer with mouse mammary tumor viruses. Recently, the Sleeping Beauty transposon system has emerged as a tool for cancer gene discovery in mouse models of human cancer. Transposons mobilized in the mouse soma can insertionally mutate cancer genes, and the transposon itself serves as a molecular “tag,” which facilitates candidate cancer gene identification. We provide an overview of some general issues related to use of Sleeping Beauty for cancer genetic studies and present here the polymerase chain reaction-based method for cloning transposon-tagged sequences from tumors.
      datePublished:2008
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      name:Chromosomal Mutagenesis
      isbn:
         978-1-59745-232-8
         978-1-58829-899-7
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      name:Humana Press
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         type:ImageObject
      name:University of Minnesota
      address:
         name:Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis
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               type:PostalAddress
            type:Organization
      name:Lara S. Collier
      affiliation:
            name:University of Minnesota
            address:
               name:Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis
      name:Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis
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