We are analyzing https://link.springer.com/protocol/10.1007/978-1-59745-210-6_10.

Title:
pH-Responsive Nanoparticles for Cancer Drug Delivery | SpringerLink
Description:
Solid tumors have an acidic extracellular environment and an altered pH gradient across their cell compartments. Nanoparticles responsive to the pH gradients are promising for cancer drug delivery. Such pH-responsive nanoparticles consist of a corona and a core, one...
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Keywords {🔍}

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Topics {✒️}

pullulan acetate/oligo-sulfonamide conjugate anti-muc1 antibody-calicheamicin conjugate temperature-sensitive acidification-defective mutants multi-drug-resistant tumour cells cisplatin-releasing ph-responsive nanoparticles atom-transfer radical polymerization luteinizing hormone-releasing hormone pullulan derivative/sulfonamide conjugate pamamdendrimer-based multifunctional conjugate long-circulating pla-peo nanoparticles gonadotropin-releasing hormone receptor glycolysis-deficient cells suggest conventional ph-insensitive counterparts long-circulating polymeric nanovectors ph-dependent cell interaction hmg-coa reductase inhibitors ph-responsive nanoparticles consist multidrug resistance-related genes layer onion-structured nanoparticles ph-sensitive biodegradable system month download article/chapter n-phenyl-2-naphthylamine ppo long-circulating polymeric micelles pei-plga diblock copolymers folate receptor-expressing tumors multidrug resistance-related phenotype ph-sensitive polymeric nanoparticles ph-sensitive drug carrier vivo anti-tumor activities multi-functional polymeric nanoparticles tumour-selective drug delivery cisplatin-incorporated polymeric micelles cisplatin-incorporating polymeric micelles long-circulating drug vehicles designed histidine-rich peptides poorly water-soluble compounds tumour-targeted drug delivery acidic ph enhances multidrug-resistance efflux pump cisplatin-resistant ovarian cancer apoptosis-related protein expression cisplatin-induced renal toxicity peo surface-modified nanoparticles anti-tumor nano-strategies sodium-potassium atpase regulation folate receptor-targeted liposomes b-peg-b-poly camptothecin derivative-loaded poly tumor-targeted drug delivery tumor-selective gene delivery

Schema {🗺️}

ScholarlyArticle:
      headline:pH-Responsive Nanoparticles for Cancer Drug Delivery
      pageEnd:216
      pageStart:183
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-59745-210-6.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Drug Delivery Systems
         isbn:
            978-1-59745-210-6
            978-1-58829-891-1
         type:Book
      publisher:
         name:Humana Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Youqing Shen
            affiliation:
                  name:University of Wyoming
                  address:
                     name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huadong Tang
            affiliation:
                  name:University of Wyoming
                  address:
                     name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maciej Radosz
            affiliation:
                  name:University of Wyoming
                  address:
                     name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Edward Van Kirk
            affiliation:
                  name:University of Wyoming
                  address:
                     name:Department of Animal Science, University of Wyoming, Laramie, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:William J. Murdoch
            affiliation:
                  name:University of Wyoming
                  address:
                     name:Department of Animal Science, University of Wyoming, Laramie, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Cancer drug delivery, Cytoplasmic drug delivery, Nanoparticles, pH-Responsive
      description:Solid tumors have an acidic extracellular environment and an altered pH gradient across their cell compartments. Nanoparticles responsive to the pH gradients are promising for cancer drug delivery. Such pH-responsive nanoparticles consist of a corona and a core, one or both of which respond to the external pH to change their soluble/insoluble or charge states. Nanoparticles whose coronas become positively charged or become soluble to make their targeting groups available for binding at the tumor extracellular pH have been developed for promoting cellular targeting and internalization. Nanoparticles whose cores become soluble or change their structures to release the carried drugs at the tumor extracellular pH or lysosomal pH have been developed for fast drug release into the extracellular fluid or cytosol. Such pH-responsive nanoparticles have therapeutic advantages over the conventional pH-insensitive counterparts.
      datePublished:2008
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Book:
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      isbn:
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         978-1-58829-891-1
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      name:Humana Press
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      name:University of Wyoming
      address:
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         type:PostalAddress
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      address:
         name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
         type:PostalAddress
      name:University of Wyoming
      address:
         name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
         type:PostalAddress
      name:University of Wyoming
      address:
         name:Department of Animal Science, University of Wyoming, Laramie, USA
         type:PostalAddress
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         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Youqing Shen
      affiliation:
            name:University of Wyoming
            address:
               name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
               type:PostalAddress
            type:Organization
      name:Huadong Tang
      affiliation:
            name:University of Wyoming
            address:
               name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
               type:PostalAddress
            type:Organization
      name:Maciej Radosz
      affiliation:
            name:University of Wyoming
            address:
               name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
               type:PostalAddress
            type:Organization
      name:Edward Van Kirk
      affiliation:
            name:University of Wyoming
            address:
               name:Department of Animal Science, University of Wyoming, Laramie, USA
               type:PostalAddress
            type:Organization
      name:William J. Murdoch
      affiliation:
            name:University of Wyoming
            address:
               name:Department of Animal Science, University of Wyoming, Laramie, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
      name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
      name:Soft Materials Laboratory, Department of Chemical and Petroleum Engineering, University of Wyoming, Laramie, USA
      name:Department of Animal Science, University of Wyoming, Laramie, USA
      name:Department of Animal Science, University of Wyoming, Laramie, USA
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