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Title:
Exploration of West Nile Virus Infection in Mouse Models | SpringerLink
Description:
West Nile virus (WNV) causes neurological diseases by penetrating the central nervous system (CNS)—an immune-privileged system. Although the CNS residential cells can produce antiviral immune responses, the blood leukocytes are required to contain virus spread....
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pubmed, west, nile, virus, article, google, scholar, central, cas, infection, wang, protocol, privacy, cookies, content, information, publish, search, mouse, wnv, immune, access, chapter, bai, download, york, springer, usd, personal, data, log, journal, research, models, penghua, phd, book, methods, biology, system, leukocytes, pathogenesis, basic, brain, virol, colpitts, microbiol, nat, dai, immunol,
Topics {βοΈ}
cd19β+βb220-bst-2+ leukocyte population month download article/chapter west nile virus penghua wang ph central nervous system west nile encephalitis privacy choices/manage cookies japanese encephalitis virus device instant download virus-induced inflammation editor information editors west nile host antiviral response mouse models protocol immune-privileged system innate immune restriction innate immune control european economic area il-22 signaling contributes munoz-jordan jl animal perfusion fixation journal finder publish immune cell recruitment conditions privacy policy basic sciences building protocol wang experimental mouse models accepting optional cookies cns residential cells main content log protocol usdΒ 49 york medical college author correspondence check access ethics access south carolina school virus spread social media permissions reprints colpitts rights diamond ms protocol cite chapter log human infection wnv infection journal publish privacy policy leukocyte numbers books a cell microbiol 13
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ScholarlyArticle:
headline:Exploration of West Nile Virus Infection in Mouse Models
pageEnd:81
pageStart:71
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-3670-0.jpg
genre:
Springer Protocols
isPartOf:
name:West Nile Virus
isbn:
978-1-4939-3670-0
978-1-4939-3668-7
type:Book
publisher:
name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Penghua Wang
affiliation:
name:School of Medicine, New York Medical College
address:
name:Department of Microbiology & Immunology, School of Medicine, New York Medical College, Valhalla, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:West Nile virus, Central nervous system, Infiltrating leukocytes, Plaque assay, Viral titration
description:West Nile virus (WNV) causes neurological diseases by penetrating the central nervous system (CNS)βan immune-privileged system. Although the CNS residential cells can produce antiviral immune responses, the blood leukocytes are required to contain virus spread. However, infiltrating leukocytes may also contribute to immunopathology if they overreact. Thus analyses of WNV infectivity and leukocyte numbers in the CNS are critical for understanding of WNV pathogenesis in experimental mouse models. Here I describe two basic assays for quantification of viral titers and infiltrating leukocytes in the mouse brain after WNV infection.
datePublished:2016
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Book:
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isbn:
978-1-4939-3670-0
978-1-4939-3668-7
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name:Springer New York
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Person:
name:Penghua Wang
affiliation:
name:School of Medicine, New York Medical College
address:
name:Department of Microbiology & Immunology, School of Medicine, New York Medical College, Valhalla, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
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