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Glucocorticoids and Cancer | SpringerLink
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Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation, and metastasis, and the androgen receptor (AR) plays a similar role in prostate...
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Keywords {🔍}
pubmed, google, scholar, article, cas, cancer, leukemia, glucocorticoid, lymphoblastic, acute, receptor, central, oncol, clin, treatment, blood, cell, glucocorticoids, chapter, patients, resistance, doijco, med, cells, glucocorticoidinduced, phase, prostate, apoptosis, doiblood, study, signaling, res, childhood, breast, chemotherapy, dexamethasone, cisplatin, privacy, cookies, content, information, publish, research, medicine, hormone, role, lymphoid, mechanisms, effect, endocrinology,
Topics {✒️}
month download article/chapter b-cell receptor signaling pi3-kinase/akt pathways small-cell lung cancer small-cell lung cancer glucocorticoid-induced leucine zipper cancer anorexia-cachexia syndrome advanced aids-related kaposi castration-resistant prostate cancer glucocorticoid-induced leukemia apoptosis ligand-induced nuclear translocation glucocorticoid-induced cell death leukaemia stem-cell development prostate cancer progression acute lymphoblastic leukemia kendall ec acute lymphoblastic leukaemia chronic lymphocytic leukemia privacy choices/manage cookies previously untreated advanced device instant download gene-expression patterns glucocorticoid-induced apoptosis glucocorticoid‐induced apoptosis glucocorticoid receptor signaling editor information editors early gene expression nuclear receptor signaling lymphoid leukemia cells mol cell biol ligand determine sensitivity rajkumar sv tumor suppressor activity hox gene promoters cell death differ cell death dis annu rev biochem transitional cell cancer steroid hormone receptors pui c reduced glucose metabolism overcome glucocorticoid resistance breast cancer ligand-independent phosphorylation prednisolone-responsive genes curr probl cancer pituitary adrenotropic hormone advanced prostate cancer phase iii study european economic area
Questions {❓}
- Glucocorticoids and prostate cancer treatment: friend or foe?
- Selective glucocorticoid receptor modulators: future of glucocorticoid immunosuppressive therapy?
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ScholarlyArticle:
headline:Glucocorticoids and Cancer
pageEnd:333
pageStart:315
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-2895-8.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
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name:Glucocorticoid Signaling
isbn:
978-1-4939-2895-8
978-1-4939-2894-1
type:Book
publisher:
name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Miles A. Pufall
affiliation:
name:Carver College of Medicine, Holden Comprehensive Cancer Center
address:
name:Department of Biochemistry, Carver College of Medicine, Holden Comprehensive Cancer Center, Iowa City, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Leukemia, Apoptosis, Lymphoma, Chemotherapy, Palliative
description:Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation, and metastasis, and the androgen receptor (AR) plays a similar role in prostate cancer. Accordingly, treatment of these diseases has focused on blocking steroid hormone receptor function. In contrast, glucocorticoids (GCs) work through GR to arrest growth and induce apoptosis in lymphoid tissue. Glucocorticoids are amazingly effective in this role, and have been deployed as the cornerstone of lymphoid cancer treatment for decades. Unfortunately, not all patients respond to GCs and dosage is restricted by immediate and long term side effects. In this chapter we review the treatment protocols that employ glucocorticoids as a curative agent, elaborate on what is known about their mechanism of action in these cancers, and also summarize the palliative uses of glucocorticoids for other cancers.
datePublished:2015
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name:Carver College of Medicine, Holden Comprehensive Cancer Center
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