We are analyzing https://link.springer.com/protocol/10.1007/978-1-4939-0357-3_7.

Title:
Detecting Caspase Activity in Drosophila Larval Imaginal Discs | SpringerLink
Description:
Caspases are a highly specialized class of cell death proteases. Since they are synthesized as inactive full-length zymogens, activation—at least of effector caspases and to some extent also of initiator caspases—requires a proteolytic cleavage event,...
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Keywords {🔍}

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Topics {✒️}

month download article/chapter rac-dependent cell migration card-carrying caspase dronc drosophila involves htra2/omi inactive full-length zymogens larval imaginal discs proteolytic cleavage event cc3 antibody cross-reacts privacy choices/manage cookies apoptosis-induced compensatory proliferation initiator caspases—requires detecting caspase activity massachusetts medical school device instant download author information authors detect caspase activity cleaving nf-κbs cell death proteases programmed cell death developmental cell death drosophila caspase dredd drosophila male terminalia caspase-mediated processing european economic area highly specialized class barber ae ii cleavage site motifs compensatory proliferation induced irvin gl iii ben-sasson sa nuclear dna fragmentation developing nervous system execution efficiencies determine journal finder publish conditions privacy policy dronc activity developing drosophila eye signals regulating effector human cleaved caspase-3 accepting optional cookies cleaved-caspase-3 antibody detects cleaved caspases main content log check access wells ja ethics access abrams jm protocol fogarty caspase activity embo rep 1

Schema {🗺️}

ScholarlyArticle:
      headline:Detecting Caspase Activity in Drosophila Larval Imaginal Discs
      pageEnd:117
      pageStart:109
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-0357-3.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Caspases,Paracaspases, and Metacaspases
         isbn:
            978-1-4939-0357-3
            978-1-4939-0356-6
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Caitlin E. Fogarty
            affiliation:
                  name:University of Massachusetts Medical School
                  address:
                     name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andreas Bergmann
            affiliation:
                  name:University of Massachusetts Medical School
                  address:
                     name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords: Drosophila , Cleaved-Caspase-3, Dronc, DrICE, Dcp-1, Cell death, Non-apoptotic function, Imaginal Disc, Immunolabeling
      description:Caspases are a highly specialized class of cell death proteases. Since they are synthesized as inactive full-length zymogens, activation—at least of effector caspases and to some extent also of initiator caspases—requires a proteolytic cleavage event, generating a large and a small subunit, two of each forming the active caspase. The proteolytic cleavage event generates neo-epitopes at both the C-terminus of the large subunit and the N-terminus of the small subunit. The cleaved Caspase-3 (CC3) antibody was raised against the neo-epitope of the large subunit and thus detects only cleaved, but not full-length, Caspase-3. Although raised against human cleaved Caspase-3, the CC3 antibody cross-reacts in other species and detects cleaved caspases, most notably DrICE and Dcp-1, in Drosophila. This protocol describes the procedure for use of the CC3 antibody to detect caspase activity in larval imaginal discs in Drosophila.
      datePublished:2014
      isAccessibleForFree:
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      context:https://schema.org
Book:
      name:Caspases,Paracaspases, and Metacaspases
      isbn:
         978-1-4939-0357-3
         978-1-4939-0356-6
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Massachusetts Medical School
      address:
         name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
         type:PostalAddress
      name:University of Massachusetts Medical School
      address:
         name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Caitlin E. Fogarty
      affiliation:
            name:University of Massachusetts Medical School
            address:
               name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
               type:PostalAddress
            type:Organization
      name:Andreas Bergmann
      affiliation:
            name:University of Massachusetts Medical School
            address:
               name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
      name:Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
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      isAccessibleForFree:
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