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Title:
Tests for Circulating Immune Complexes | SpringerLink
Description:
Antigen–antibody complexes in tissues play a central role in the pathogenesis of lupus. Some of the immune complexes are formed in situ, i.e., in the tissues. Others are present in the blood stream, and these circulating immune complexes may deposit in tissues...
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Keywords {🔍}

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Topics {✒️}

month download article/chapter enzyme-linked immunosorbent assay c1q solid-phase assay anti-c1q capture assay polyethylene glycol-immunoglobulin c1q-binding immune complexes antigen-antibody complexes systemic lupus erythematosus privacy choices/manage cookies device instant download editor information editors measuring immunoconglutinins directed anti-c1q autoantibodies deposit anti dsdna antibody circulating immune complexes detecting immune-complexes van schaarenburg ra serum immune complexes central role european economic area incite inflammatory mechanisms high salt concentration autoimmune rheumatic diseases trouw la journal finder publish conditions privacy policy chapter describes methods exeter medical school anti-c3b autoantibodies accepting optional cookies sle include approaches anti-c1q autoantibodies raji cell methods anti-c1q antibodies main content log protocol usd 49 wener mh c1q-binding dixon fj protocol cite social media schur ph permissions reprints protocol wener immune complexes nies km check access ethics access humana press human complement

Schema {🗺️}

ScholarlyArticle:
      headline:Tests for Circulating Immune Complexes
      pageEnd:57
      pageStart:47
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-0326-9.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Systemic Lupus Erythematosus
         isbn:
            978-1-4939-0326-9
            978-1-4939-0325-2
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mark H. Wener
            affiliation:
                  name:University of Washington
                  address:
                     name:Department of Laboratory Medicine, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Washington
                  address:
                     name:Rheumatology Division, Department of Medicine, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:C1q, Complement proteins, Collagen-like region, Globular head, Immune complexes, Lupus nephritis
      description:Antigen–antibody complexes in tissues play a central role in the pathogenesis of lupus. Some of the immune complexes are formed in situ, i.e., in the tissues. Others are present in the blood stream, and these circulating immune complexes may deposit in tissues and incite inflammatory mechanisms in those tissues. A variety of techniques are available to measure circulating immune complexes. The assays that have been most studied in SLE include approaches that rely on the interaction of immune complexes with complement proteins, and therefore bind to C1q or contain bound C3. In the process of investigating circulating immune complexes, it was recognized that lupus patients generate serum autoantibodies directed against C1q and other complement proteins. Antibodies reacting with the collagen-like region of C1q are known to be closely linked both clinically and pathophysiologically to lupus nephritis. This chapter describes methods for detection of C1q-binding immune complexes via the C1q solid-phase assay and the related test for autoantibodies to C1q.
      datePublished:2014
      isAccessibleForFree:
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         type:WebPageElement
      context:https://schema.org
Book:
      name:Systemic Lupus Erythematosus
      isbn:
         978-1-4939-0326-9
         978-1-4939-0325-2
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Washington
      address:
         name:Department of Laboratory Medicine, University of Washington, Seattle, USA
         type:PostalAddress
      name:University of Washington
      address:
         name:Rheumatology Division, Department of Medicine, University of Washington, Seattle, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Mark H. Wener
      affiliation:
            name:University of Washington
            address:
               name:Department of Laboratory Medicine, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
            name:University of Washington
            address:
               name:Rheumatology Division, Department of Medicine, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Laboratory Medicine, University of Washington, Seattle, USA
      name:Rheumatology Division, Department of Medicine, University of Washington, Seattle, USA
WebPageElement:
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