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Title:
Human Tumor Xenograft Models in NCI Drug Development | SpringerLink
Description:
The preclinical discovery and development of anticancer drugs by the NCI consist of a series of test procedures, data review, and decision steps that have been summarized recently (1). Test procedures are designed to provide comparative quantitative data, which in...
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google, scholar, cancer, cas, human, pubmed, tumor, drug, development, res, cell, article, mice, lines, anticancer, chapter, nci, dykes, eds, nude, research, discovery, antitumor, national, institute, plowman, agents, vivo, vol, screening, tumors, abbott, proc, assoc, models, alley, preclinical, program, chemotherapy, venditti, york, boyd, natl, inst, metastasis, cells, mayo, growth, privacy, cookies,
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month download article/chapter lymphoma-derived cell lines anti-cancer drug validation tumor colony-forming units murine tumor models lymphoma cell line drug research program european economic area active lead compounds cell lines derived nci drug development human breast carcinomas cell lines positive privacy choices/manage cookies cancer drug discovery national cancer institute human tumor xenografts human tumor cloning human malignant tumor preclinical drug development severe combined immunodeficiency device instant download human malignant tumors tumor cell response nci committees serve human lung cancers human nm23-hl human undifferentiated lymphomas cancer treatment research vivo antitumor activity hollow fiber assay national chemotherapy program tumor metastatic potential melinda hollingshead phd devita vt jr tumor panel screening preexisting variant cells human cancer metastasis natural killer cells complement receptor expression transplantable tumor systems assessing chemotherapeutic agents triazine mimic antibiotics bioorganic marine chemistry wolpert-defilippes mk von hoff dd induced complement receptors american undifferentiated lymphomas phosphatidy- linositol turnover involves tyrosine phosphorylation
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ScholarlyArticle:
headline:Human Tumor Xenograft Models in NCI Drug Development
pageEnd:125
pageStart:101
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4615-8152-9.jpg
genre:
Medicine
Medicine (R0)
isPartOf:
name:Anticancer Drug Development Guide
isbn:
978-1-4615-8152-9
978-1-4615-8154-3
type:Book
publisher:
name:Humana Press
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Jacqueline Plowman
affiliation:
type:Person
name:Donald J. Dykes
affiliation:
type:Person
name:Melinda Hollingshead
affiliation:
type:Person
name:Linda Simpson-Herren
affiliation:
type:Person
name:Michael C. Alley
affiliation:
type:Person
keywords:Hollow Fiber, Test Agent, Athymic Mouse, Human Tumor Xenograft, Human Tumor Xenograft Model
description:The preclinical discovery and development of anticancer drugs by the NCI consist of a series of test procedures, data review, and decision steps that have been summarized recently (1). Test procedures are designed to provide comparative quantitative data, which in turn, permit selection of the best candidate agents from a given chemical or biological class. Periodic, comprehensive reviews by various NCI committees serve not only to identify and expedite the development of active lead compounds that may provide more efficacious treatments for human malignancy, but also to eliminate agents that are inactive and/or highly toxic from further consideration.
datePublished:1997
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name:Humana Press
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name:Jacqueline Plowman
affiliation:
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affiliation:
name:Melinda Hollingshead
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