We are analyzing https://link.springer.com/chapter/10.1007/978-1-4614-7783-9_6.

Title:
Protamine Alterations in Human Spermatozoa | SpringerLink
Description:
Protamines are the major nuclear proteins in sperm cells, having a crucial role in the correct packaging of the paternal DNA. The fact that protamine haploinsufficiency in mice resulted in abnormal chromatin packaging and male infertility suggested that the...
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Keywords {🔍}

google, scholar, pubmed, cas, protamine, sperm, human, reprod, biol, oliva, protamines, mol, male, hum, spermatozoa, infertile, infertility, genes, dna, protein, androl, chromatin, gene, men, chapter, nuclear, patients, proteomics, proteomic, med, analysis, mrna, res, mateo, content, proteins, cells, expression, evolution, biochem, identification, damage, liu, mammalian, syst, genetic, mice, castillo, structure, biophys,

Topics {✒️}

post-meiotic male genome month download article/chapter trans-acting factors binding eirin-lopez jm genome-wide study genome-wide analysis identifies protamine-deficient human sperm protamine-encoding p1 genes privacy choices/manage cookies amino-acid sequences device instant download aoki vw editor information editors arrests spermatid differentiation nucleosome core particle ctcf binding sequences ministerio de economia p1/p2 ratios mature sperm cell cumulative birth rates bazett-jones dp depa-martynow abnormal sperm morphology precocious nuclear condensation vidal-taboada jm nuclear matrix interactions human sperm nucleus human ejaculated sperm high promoter divergence anomalous protein complement chapter genetic damage imprinted gene loci human male infertility european economic area approximately equal quantities endogenous metabolic pathways poor fertilizing capacity complete selective absence elemental packing unit atomic force microscopy assisted reproduction outcomes human spermatozoa chapter major nuclear proteins human protamine p4 minor basic protein higher sperm counts infertile human males sperm nuclear proteins sperm chromatin condensation protein expression identified

Questions {❓}

Iguchi N, Yang S, Lamb DJ et al (2006) An SNP in protamine 1: a possible genetic cause of male infertility?
Imken L, Rouba H, El Houate B et al (2009) Mutations in the protamine locus: association with spermatogenic failure?

Schema {🗺️}

ScholarlyArticle:
      headline:Protamine Alterations in Human Spermatozoa
      pageEnd:102
      pageStart:83
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-7783-9.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Genetic Damage in Human Spermatozoa
         isbn:
            978-1-4614-7783-9
            978-1-4614-7782-2
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Meritxell Jodar
            affiliation:
                  name:University of Barcelona
                  address:
                     name:Human Genetics Research Group, IDIBAPS, University of Barcelona, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rafael Oliva
            affiliation:
                  name:Clinic Hospital
                  address:
                     name:Biochemistry and Molecular Genetics Service, Clinic Hospital, Barcelona, Spain
                     type:PostalAddress
                  type:Organization
                  name:University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
                  address:
                     name:Faculty of Medicine, University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Protamine genes, Protamine transcripts, Protamine proteins, Spermatozoa
      description:Protamines are the major nuclear proteins in sperm cells, having a crucial role in the correct packaging of the paternal DNA. The fact that protamine haploinsufficiency in mice resulted in abnormal chromatin packaging and male infertility suggested that the protamines could also be important candidates in explaining some of the idiopathic male infertility cases in humans. The first clinical studies focused on analyzing protamines at the protein level. Various studies have found the presence of an altered amount of protamines in some infertile patients, in contrast to the normal situation in fertile individuals where the two protamines, protamine 1 and protamine 2, are both present in approximately equal quantities. Subsequently, the protamine genes were the subject of various mutational genetic screening studies in search of variants that could be associated with deregulation in the protamine expression observed. The results of these protamine mutational studies showed that the presence of high penetrant mutations is a very rare cause of male infertility. However, some variants and some haplotypes described may behave as risk factors for male infertility. More recently, the presence of RNA in the mature sperm cell has also been investigated. The present chapter will introduce the basic aspects of protamine evolution and function and review the various articles published to date on the relationship between the protamines studied at the DNA, RNA, and protein levels and male infertility.
      datePublished:2014
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Book:
      name:Genetic Damage in Human Spermatozoa
      isbn:
         978-1-4614-7783-9
         978-1-4614-7782-2
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Barcelona
      address:
         name:Human Genetics Research Group, IDIBAPS, University of Barcelona, Barcelona, Spain
         type:PostalAddress
      name:Clinic Hospital
      address:
         name:Biochemistry and Molecular Genetics Service, Clinic Hospital, Barcelona, Spain
         type:PostalAddress
      name:University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
      address:
         name:Faculty of Medicine, University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
         type:PostalAddress
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Person:
      name:Meritxell Jodar
      affiliation:
            name:University of Barcelona
            address:
               name:Human Genetics Research Group, IDIBAPS, University of Barcelona, Barcelona, Spain
               type:PostalAddress
            type:Organization
      name:Rafael Oliva
      affiliation:
            name:Clinic Hospital
            address:
               name:Biochemistry and Molecular Genetics Service, Clinic Hospital, Barcelona, Spain
               type:PostalAddress
            type:Organization
            name:University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
            address:
               name:Faculty of Medicine, University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Human Genetics Research Group, IDIBAPS, University of Barcelona, Barcelona, Spain
      name:Biochemistry and Molecular Genetics Service, Clinic Hospital, Barcelona, Spain
      name:Faculty of Medicine, University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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