We are analyzing https://link.springer.com/chapter/10.1007/978-1-4614-5915-6_2.

Title:
Hypoxia and Regulation of Cancer Cell Stemness | SpringerLink
Description:
Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell “stemness.” Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic...
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

google, scholar, pubmed, article, cas, cancer, cell, cells, tumor, stem, hypoxia, hifα, expression, res, biol, yun, regulation, hypoxiainducible, human, lin, hypoxic, mol, gene, microenvironment, sci, differentiation, nature, nat, breast, proc, natl, acad, giaccia, factor, stemness, potential, chapter, prognostic, kim, proliferation, tumour, oct, rev, metastasis, springer, privacy, cookies, content, information, publish,

Topics {✒️}

circulating human epidermal-growth-factor hif-1-regulated gene dec1/stra13 hypoxia-inducible factor-1-dependent regulation multi-lineage differentiation capacity von hippel-lindau protein hypoxia-inducible factor-1α hypoxia-inducible factor pathway hypoxia-inducible factor 1α month download article/chapter hif-2α regulates oct-4 akt-mediated melanocyte transformation microenvironment-induced cancer metastasis slow-cycling melanoma cells o2-regulated prolyl hydroxylation hypoxia-regulated pathways implicated loco-regional tumor control de la torre-ubieta hypoxia-inducible factor stat3-mediated nanog regulation glioma stem cells histone demethylase jmjd1a vhl-mediated destruction privacy choices/manage cookies pluripotent stem cells enhances metastatic potential key regulatory factor van sluis pg hypoxic tumour microenvironment life sciences biomedical device instant download hypoxia promotes expansion van noesel cj pparγ2 gene expression tumor-initiating cells hypoxic tumor microenvironment cell fate decisions stem cell theory cd44-/cd24+ tumor cells human neuroblastoma cells tumor suppressor role hif-2α promotes adult human fibroblasts hypoxic cancer cells invasive breast carcinomas cancer stem cells hypoxia-mediated apoptosis hypoxia-mediated selection tumor suppressive potential diminished apoptotic potential oxygen-dependent proteolysis

Questions {❓}

Floridon C, Jensen CH, Thorsen P, Nielsen O, Sunde L, Westergaard JG, Thomsen SG, Teisner B (2000) Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials?
Marusyk A, Almendro V, Polyak K (2012) Intra-tumour heterogeneity: a looking glass for cancer?

Schema {🗺️}

ScholarlyArticle:
      headline:Hypoxia and Regulation of Cancer Cell Stemness
      pageEnd:53
      pageStart:41
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4614-5915-6.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Tumor Microenvironment and Cellular Stress
         isbn:
            978-1-4614-5915-6
            978-1-4614-5914-9
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Zhong Yun
            affiliation:
                  name:Yale School of Medicine
                  address:
                     name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Qun Lin
            affiliation:
                  name:Yale School of Medicine
                  address:
                     name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Cancer stem cells, Differentiation, Hypoxia, Progenitor cells, Tumor microenvironment
      description:Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell “stemness.” Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic capabilities are identified, suggesting that the tumor microenvironment can exert a significant effect on the evolution of different clonal populations. Hypoxia is a common feature of tumor microenvironments and has the potential to facilitate malignant progression. This chapter provides a synopsis of hypoxia-regulated pathways implicated in the maintenance of cancer stem cells.
      datePublished:2014
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
      context:https://schema.org
Book:
      name:Tumor Microenvironment and Cellular Stress
      isbn:
         978-1-4614-5915-6
         978-1-4614-5914-9
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Yale School of Medicine
      address:
         name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
         type:PostalAddress
      name:Yale School of Medicine
      address:
         name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Zhong Yun
      affiliation:
            name:Yale School of Medicine
            address:
               name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Qun Lin
      affiliation:
            name:Yale School of Medicine
            address:
               name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
      name:Department of Therapeutic Radiology, Yale School of Medicine, New Haven, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(315)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js

CDN Services {📦}

Pbgrd

4.86s.

LINK . SPRINGER . COM {}