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Profiling Epigenetic Alterations in Disease | SpringerLink
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Nowadays, epigenetics is one of the fastest growing research areas in biomedicine. Studies have demonstrated that changes in the epigenome are not only common in cancer, but are also involved in the pathogenesis of noncancerous diseases like immunological,...
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- Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction?
- Stem cell chromatin patterns: an instructive mechanism for DNA hypermethylation?
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ScholarlyArticle:
headline:Profiling Epigenetic Alterations in Disease
pageEnd:177
pageStart:162
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4419-8216-2.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Epigenetic Contributions in Autoimmune Disease
isbn:
978-1-4419-8216-2
978-1-4419-8215-5
type:Book
publisher:
name:Springer US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:José Ignacio Martín-Subero
affiliation:
name:Bellvitge Biomedical Research Institute (IDIBELL)
address:
name:Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
type:PostalAddress
type:Organization
type:Person
name:Manel Esteller
affiliation:
name:Bellvitge Biomedical Research Institute (IDIBELL)
address:
name:Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
type:PostalAddress
type:Organization
type:Person
keywords:Cancer Epigenetic, Epigenome Project, Human Epigenome Project, Human Methylome
description:Nowadays, epigenetics is one of the fastest growing research areas in biomedicine. Studies have demonstrated that changes in the epigenome are not only common in cancer, but are also involved in the pathogenesis of noncancerous diseases like immunological, cardiovascular, developmental and neurological/psychiatric disorders. At the same time, during the last years, a technological revolution has taken place in the field of epigenomics, which is defined as the study of epigenetic changes throughout the whole genome. Microarray technologies and more recently, the development of next generation sequencing devices are now providing researchers with tools to draw high-resolution maps of DNA methylation and histone modifications in normal tissues and diseases. This chapter will review the currently available high-throughput techniques for studying the epigenome and their applications for characterizing human diseases.
datePublished:2011
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name:Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
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