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Autophagy and Longevity: Lessons from C. elegans | SpringerLink
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Aging is a process in which individuals undergo an exponential decline in vitality, leading to death. In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our...
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google, scholar, pubmed, cas, article, elegans, autophagy, cell, aging, caenorhabditis, life, longevity, span, lifespan, protein, dev, chapter, mitochondrial, nature, science, biol, kinase, restriction, genes, regulation, signaling, dietary, usa, metabolism, jia, levine, pathway, role, gene, genetics, daf, insulin, sci, extension, death, ageing, regulates, stress, acad, development, cells, rev, oxidative, wang, privacy,
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ScholarlyArticle:
headline:Autophagy and Longevity: Lessons from C. elegans
pageEnd:60
pageStart:47
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4419-7002-2.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:Protein Metabolism and Homeostasis in Aging
isbn:
978-1-4419-7002-2
978-1-4419-7001-5
type:Book
publisher:
name:Springer US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Kailiang Jia
affiliation:
name:Florida Atlantic University
address:
name:Florida Atlantic University, Boca Raton, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Beth Levine
affiliation:
name:HHMI
address:
name:Southwestern Medical Center, HHMI, Dallas, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Life Span, Dietary Restriction, Life Span Extension, Evity Pathway, Pheromone Level
description:
Aging is a process in which individuals undergo an exponential decline in vitality, leading to death. In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our knowledge of aging. Multiple longevity pathways, such as insulin-like growth factor signaling, TOR signaling, dietary restriction and mitochondrial activity, control aging in C. elegans. Recent genetic studies indicate that autophagy, an evolutionary conserved lysosomal degradation pathway, interacts with various longevity signals in the regulation of C. elegans life span. Here, we review the current progress in understanding the role of autophagy in the regulation of C. elegans life span.
datePublished:2010
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