We are analyzing https://link.springer.com/chapter/10.1007/978-1-4419-1241-1_2.

Title:
Cell Respiration Under Hypoxia: Facts and Artefacts in Mitochondrial Oxygen Kinetics | SpringerLink
Description:
When oxygen supply to tissues is limiting, mitochondrial respiration and ATP production are compromised. To assess the bioenergetic consequences under normoxia and hypoxia, quantitative evaluation of mitochondrial oxygen kinetics is required. Using high-resolution...
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Keywords {🔍}

google, scholar, oxygen, pubmed, cas, article, respiration, mitochondrial, physiol, gnaiger, cell, cells, respiratory, innsbruck, mitochondria, biophys, kinetics, biol, cellular, isolated, cytochrome, low, dependence, content, oxidase, chapter, usa, phosphorylation, biochim, acta, hypoxic, springer, privacy, cookies, function, information, publish, research, paper, hypoxia, kpa, affinity, control, chem, biochem, life, university, data, search, transport,

Topics {✒️}

month download article/chapter long-term hypoxic rats 32d-vraf cell lines steady-state oxygen tension mouse skeletal muscle privacy choices/manage cookies human gastrocnemius muscle swarovski research laboratory device instant download oroboros mipnet publications primary human fibroblasts tissue xxxi francesca low blood flow regulates superoxide production respiratory electron transport mitochondrial po2 measured inhibited oxygen consumption oxygen pressure gradients steinlechner-maran european economic area high-resolution respirometry clark-type electrode drug-induced toxicity modern trends biothermokinetics brookes ps sensitive toxicological test author information authors editor information editors mitochondrial function measured steady-state values enhanced o2 affinity anoxic cell core single isolated cardiomyocyte cardiac myocytes isolated isolated cardiac myocytes polarographic oxygen sensors respiratory flux control integrated functional activity adenosine diphosphate supply leigh syndrome caused mitochondrial oxygen kinetics biphasic oxygen kinetics low oxygen environment low oxygen concentrations low oxygen tensions digital data analysis coronary endothelial cells hypoxic cell signaling oxygen diffusion interference measuring oxygen concentration

Questions {❓}

In Gnaiger E, Gellerich FN, Wyss M (ed) What is controlling life?
Mendez G, Gnaiger E (1994) How does oxygen pressure control oxygen flux in isolated mitochondria?

Schema {🗺️}

ScholarlyArticle:
      headline:Cell Respiration Under Hypoxia: Facts and Artefacts in Mitochondrial Oxygen Kinetics
      pageEnd:25
      pageStart:7
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4419-1241-1.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Oxygen Transport to Tissue XXXI
         isbn:
            978-1-4419-1241-1
            978-1-4419-1239-8
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Francesca M. Scandurra
            affiliation:
                  name:Medical University of Innsbruck
                  address:
                     name:Department of General and Transplant Surgery, D. Swarovski Research Laboratory, Medical University of Innsbruck, Innsbruck, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Erich Gnaiger
            affiliation:
                  name:Medical University of Innsbruck
                  address:
                     name:D. Swarovski Research Laboratory, Department of General and Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria
                     type:PostalAddress
                  type:Organization
                  name:OROBOROS INSTRUMENTS
                  address:
                     name:OROBOROS INSTRUMENTS, Innsbruck, Austria
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Human Umbilical Vein Endothelial Cell, Mitochondrial Respiration, Oxygen Flow, Heart Mitochondrion, Oxygen Flux
      description:When oxygen supply to tissues is limiting, mitochondrial respiration and ATP production are compromised. To assess the bioenergetic consequences under normoxia and hypoxia, quantitative evaluation of mitochondrial oxygen kinetics is required. Using high-resolution respirometry, the “apparent K m” for oxygen or p 50 of respiration in 32D cells was determined at 0.05 ± 0.01 kPa (0.4 mmHg, 0.5 μM, 0.25% air saturation). Close agreement with p 50 of isolated mitochondria indicates that intracellular gradients are small in small cells at routine activity. At intracellular p O2 <2 kPa (15 mmHg, 10% air saturation) in various tissues under normoxia, respiration is limited by >2% with a p 50 of 0.05 kPa. Over-estimation of p 50 at 0.4 kPa (3 mmHg) would imply significant (>17%) oxygen limitation of respiration under intracellular normoxia. Based on a critical review, we conclude that p 50 ranges from 0.01 to 0.10 kPa in mitochondria and small cells in the absence of inhibitors of cytochrome c oxidase, whereas experimental artefacts explain the controversial >200-fold range of p 50 in the literature on mitochondrial oxygen kinetics.
      datePublished:2010
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         978-1-4419-1239-8
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      name:Springer US
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical University of Innsbruck
      address:
         name:Department of General and Transplant Surgery, D. Swarovski Research Laboratory, Medical University of Innsbruck, Innsbruck, Austria
         type:PostalAddress
      name:Medical University of Innsbruck
      address:
         name:D. Swarovski Research Laboratory, Department of General and Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria
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      name:Francesca M. Scandurra
      affiliation:
            name:Medical University of Innsbruck
            address:
               name:Department of General and Transplant Surgery, D. Swarovski Research Laboratory, Medical University of Innsbruck, Innsbruck, Austria
               type:PostalAddress
            type:Organization
      name:Erich Gnaiger
      affiliation:
            name:Medical University of Innsbruck
            address:
               name:D. Swarovski Research Laboratory, Department of General and Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria
               type:PostalAddress
            type:Organization
            name:OROBOROS INSTRUMENTS
            address:
               name:OROBOROS INSTRUMENTS, Innsbruck, Austria
               type:PostalAddress
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      email:[email protected]
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      name:Department of General and Transplant Surgery, D. Swarovski Research Laboratory, Medical University of Innsbruck, Innsbruck, Austria
      name:D. Swarovski Research Laboratory, Department of General and Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria
      name:OROBOROS INSTRUMENTS, Innsbruck, Austria
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