We are analyzing https://link.springer.com/chapter/10.1007/978-1-4020-8831-5_16.

Title:
Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics | SpringerLink
Description:
In this chapter, roles of bioactive sphingolipids in the regulation of cancer pathogenesis and therapy will be reviewed. Sphingolipids have emerged as bioeffector molecules, which control various aspects of cell growth, proliferation, and anti-cancer therapeutics....
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Keywords {🔍}

google, scholar, cas, pubmed, article, cancer, ceramide, biol, hannun, cell, chem, cells, obeid, apoptosis, human, kinase, sphingosine, bielawska, ogretmen, res, bielawski, growth, resistance, role, sphingolipids, synthase, protein, sphingolipid, inhibition, tumor, szulc, regulation, metabolism, death, drug, biophys, synthesis, biochim, acta, activity, liu, lett, wang, sphingomyelin, spiegel, merrill, breast, mol, cabot, prostate,

Topics {✒️}

controlling c-myc/max function alkyl-lysophospholipid-induced apoptosis due c26-coa-dependent ceramide synthesis nuclear glyceraldehyde-3-phosphate dehydrogenase selectively utilizes palmitoyl-coa anti-sphingosine-1-phosphate antibody fumonisin b1-independent manner lymphotoxin-induced oligodendrocyte death low-affinity neurotrophin receptor chemotherapy-induced cell death ceramide-mediated signal transduction fatty acyl-coa donors ceramide-activated protein phosphatase regulates n-stearoyl-sphinganine n-hexanoyl-sphingomyelin potentiates programmed cell death ceramide-mediated telomerase inhibition sp1/sp3-dependent regulation ceramide-mediated growth inhibition van der spoel 2-dimethylhydrazine-treated cf1 mice lipid-mediated cell regulation activates protein kinase sphingosine kinase-1 activates colonic cell proliferation prostate adenocarcinoma cell inhibits ceramide formation privacy choices/manage cookies inhibits tumor growth fatty acid precursors p38-dependent manner generating death signals sphingosine 1-phosphate receptor-1 cell death differ drug-induced apoptosis protein kinase czeta apoptotic cell death cationic pyridinium-ceramide reverse drug resistance sphingolipid-mediated responses vivo rna interference p38-dependent pathways bid-mediated caspase-9 neuroblastoma cell lines acid ceramidase inhibition tumor necrosis factor acid ceramidase overexpression human melanoma cells ceramide-induced apoptosis cd95/fas-induced

Questions {❓}

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?

Schema {🗺️}

ScholarlyArticle:
      headline:Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics
      pageEnd:440
      pageStart:413
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4020-8831-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Lipids in Health and Disease
         isbn:
            978-1-4020-8831-5
            978-1-4020-8830-8
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sahar A. Saddoughi
            affiliation:
            type:Person
            name:Pengfei Song
            affiliation:
            type:Person
            name:Besim Ogretmen
            affiliation:
                  name:Medical University of South Carolina, Medical University of South Carolina
                  address:
                     name:Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Medical University of South Carolina, Charleston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Apoptosis, Ceramide, Drug Resistance, Cancer Therapeutics, Sphingolipids
      description:In this chapter, roles of bioactive sphingolipids in the regulation of cancer pathogenesis and therapy will be reviewed. Sphingolipids have emerged as bioeffector molecules, which control various aspects of cell growth, proliferation, and anti-cancer therapeutics. Ceramide, the central molecule of sphingolipid metabolism, generally mediates anti-proliferative responses such as inhibition of cell growth, induction of apoptosis, and/or modulation of senescence. On the other hand, sphingosine 1-phosphate (S1P) plays opposing roles, and induces transformation, cancer cell growth, or angiogenesis. A network of metabolic enzymes regulates the generation of ceramide and S1P, and these enzymes serve as transducers of sphingolipid-mediated responses that are coupled to various exogenous or endogenous cellular signals. Consistent with their key roles in the regulation of cancer growth and therapy, attenuation of ceramide generation and/or increased S1P levels are implicated in the development of resistance to drug-induced apoptosis, and escape from cell death. These data strongly suggest that advances in the molecular and biochemical understanding of sphingolipid metabolism and function will lead to the development of novel therapeutic strategies against human cancers, which may also help overcome drug resistance.
      datePublished:2008
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Book:
      name:Lipids in Health and Disease
      isbn:
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         978-1-4020-8830-8
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      name:Springer Netherlands
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         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical University of South Carolina, Medical University of South Carolina
      address:
         name:Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Medical University of South Carolina, Charleston, USA
         type:PostalAddress
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      name:Sahar A. Saddoughi
      affiliation:
      name:Pengfei Song
      affiliation:
      name:Besim Ogretmen
      affiliation:
            name:Medical University of South Carolina, Medical University of South Carolina
            address:
               name:Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Medical University of South Carolina, Charleston, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Medical University of South Carolina, Charleston, USA
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