We are analyzing https://link.springer.com/chapter/10.1007/978-1-4020-6554-5_2.

Title:
Caspase Mechanisms | SpringerLink
Description:
The main effectors of apoptosis encompass proteases from the caspase family, which reside as latent precursors in most nucleated animal cells. The apoptotic caspases constitute a minimal two-step signaling pathway. The apical (initiator) caspases are activated within...
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Caspase Mechanisms
      pageEnd:23
      pageStart:13
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4020-6554-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Programmed Cell Death in Cancer Progression and Therapy
         isbn:
            978-1-4020-6554-5
            978-1-4020-6553-8
         type:Book
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Guy S. Salvesen
            affiliation:
                  name:Burnham Institute for Medical Research
                  address:
                     name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan J. Riedl
            affiliation:
                  name:Burnham Institute for Medical Research
                  address:
                     name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:apoptosome, caspase, DISC, IAP, inhibition, protease, zymogen
      description:The main effectors of apoptosis encompass proteases from the caspase family, which reside as latent precursors in most nucleated animal cells. The apoptotic caspases constitute a minimal two-step signaling pathway. The apical (initiator) caspases are activated within oligomeric signaling complexes in response to apoptotic stimuli. Their mechanism of activation probably results from proximity-induced clustering to the dimeric active forms. Once activated, the apical caspases directly activate the executioner (effector) caspases by limited proteolytic cleavage. The distinct activation mechanisms explain how an apoptotic stimulus is converted to proteolytic activity, and how this activity is amplified to allow for limited proteolysis of the dozens of protein substrates whose cleavage is required for efficient apoptosis.
      datePublished:2008
      isAccessibleForFree:
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Book:
      name:Programmed Cell Death in Cancer Progression and Therapy
      isbn:
         978-1-4020-6554-5
         978-1-4020-6553-8
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Burnham Institute for Medical Research
      address:
         name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
         type:PostalAddress
      name:Burnham Institute for Medical Research
      address:
         name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Guy S. Salvesen
      affiliation:
            name:Burnham Institute for Medical Research
            address:
               name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Stefan J. Riedl
      affiliation:
            name:Burnham Institute for Medical Research
            address:
               name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
      name:Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, La Jolla, USA
WebPageElement:
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