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Mitochondrial Oscillations in Physiology and Pathophysiology | SpringerLink
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Oscillations in chemical reactions and metabolic pathways have historiacally served as prototypes for understanding the dynamics of complex nonlinear systems. This chapter reviews the oscillatory behavior of mitochondria, with a focus on the mitochondrial oscillator...
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ScholarlyArticle:
headline:Mitochondrial Oscillations in Physiology and Pathophysiology
pageEnd:117
pageStart:98
image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-09794-7.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
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name:Cellular Oscillatory Mechanisms
isbn:
978-0-387-09794-7
978-0-387-09793-0
type:Book
publisher:
name:Springer New York
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url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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type:Organization
author:
name:Miguel A. Aon
affiliation:
name:The Johns Hopkins University
address:
name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
type:PostalAddress
type:Organization
type:Person
name:Sonia Cortassa
affiliation:
name:The Johns Hopkins University
address:
name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
type:PostalAddress
type:Organization
type:Person
name:Brian O’Rourke
affiliation:
name:The Johns Hopkins University
address:
name:Division of Cardiology Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Reactive Oxygen Species Production, Mitochondrial Membrane Potential, Permeability Transition Pore, Mitochondrial Reactive Oxygen Species, Reactive Oxygen Species Accumulation
description:Oscillations in chemical reactions and metabolic pathways have historiacally served as prototypes for understanding the dynamics of complex nonlinear systems. This chapter reviews the oscillatory behavior of mitochondria, with a focus on the mitochondrial oscillator dependent on reactive oxygen species (ROS), as first described in heart cells. Experimental and theoretical evidence now indicates that mitochondrial energetic variables oscillate autonomously as part of a network of coupled oscillators under both physiological and pathological conditions. The physiological domain is characterized by small-amplitude oscillations in mitochondrial membrane potential (ΔΨm) showing correlated behavior over a wide range of frequencies, as determined using Power Spectral Analysis and Relative Dispersion Analysis of long term recordings of ΔΨm. Under metabolic stress, when the balance between ROS generation and ROS scavenging is perturbed, the mitochondrial network throughout the cell locks to one main low-frequency, high-amplitude oscillatory mode. This behavior has major pathological implications because the energy dissipation and cellular redox changes that occur during ΔΨm depolarization result in suppression of electrical excitability and Ca2+ handling, the two main functions of the cardiac cell. In an ischemia/reperfusion scenario these alterations scale up to the level of the whole organ, giving rise to fatal arrhythmias.
datePublished:2008
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